Headshot of Adrian Lita

Adrian Lita, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Neuro-Oncology Branch


Dr. Lita is an inorganic chemist in the Cancer Metabolism Research Program at the Neuro-Oncology Branch (NOB), who specializes in Raman spectroscopy. His goals are to develop methods to image lipids in organelles of live cells and tissue. He is combining Raman spectroscopy with confocal microscopy to study lipids in single cells present in the tissue microenvironment. He is also combining Raman spectroscopy with artificial intelligence to investigate gliomas and discover novel tumor biology specific to each tumor class.

Explore the NOB's Research Programs >

Areas of Expertise

Cancer Metabolism
Cancer Imaging
Tumor Microenvironment
Raman Spectroscopy
Diagnostics And Biomarkers
Molecular Mechanisms Of Cancer


Probabilistic model checking of cancer metabolism

Friedenberg MD, Lita A, Gilbert MR, Larion M, Celiku O
Scientific Reports. 12(1): 18870, 2022. [ Journal Article ]

Advances in measuring cancer cell metabolism with subcellular resolution

Ruiz-Rodado V, Lita A, Larion M
Nature Methods. 19(9): 1048-1063, 2022. [ Journal Article ]

Single-Organelle Optical Omics Platform for Cell Science and Biomarker Discovery

Pliss A, Kuzmin AN, Lita A, Kumar R, Celiku O, Atilla-Gokcumen GE, Gokcumen O, Chandra D, Larion M, Prasad PN
Analytical Chemistry. 93(23): 8281-8290, 2021. [ Journal Article ]

IDH1 mutations induce organelle defects via dysregulated phospholipids.

Lita A, Pliss A, Kuzmin A, Yamasaki T, Zhang L, Dowdy T, Burks C, de Val N, Celiku O, Ruiz-Rodado V, Nicoli ER, Kruhlak M, Andresson T, Das S, Yang C, Schmitt R, Herold-Mende C, Gilbert MR, Prasad PN, Larion M
Nature Communications. 12(1): 614, 2021. [ Journal Article ]

Toward Single-Organelle Lipidomics in Live Cells

Lita A, Kuzmin AN, Pliss A, Baev A, Rzhevskii A, Gilbert MR, Larion M, Prasad PN
Analytical Chemistry. 91(17): 11380-11387, 2019. [ Journal Article ]


A triptych of brain tissue under optical microscope and a Raman imaging microscope

Building a Toolkit to Examine How Cancer Cells Redirect Their Energy

November 28, 2022

A technique called Raman spectroscopy has revolutionized the way Dr. Mioara Larion’s lab understands tumor cell metabolism—and may ultimately help researchers design more effective cancer drugs. Read more >