Breadcrumb

John T. Schiller, Ph.D.

John T. Schiller, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Schiller and his co-PI, Dr. Douglas Lowy, led the initial development and characterization of the human papillomavirus (HPV) prophylactic vaccines that ultimately became the commercial vaccines Cervarix and Gardasil. They currently study basic aspects of the papillomavirus life cycle, second-generation HPV vaccines, and HPV capsid-based vaccines against other infection agents and cancers. The lab is also developing cancer therapies based on the preferential binding of HPV capsids to tumor cells.

Areas of Expertise

1) papillomaviruses 2) prophylactic vaccines 3) therapeutic vaccines 4) virus infection 5) virus assembly 6) serology

Publications

Selected Key Publications

A Prime-Pull-Amplify Vaccination Strategy To Maximize Induction of Circulating and Genital-Resident Intraepithelial CD8+ Memory T Cells

Cuburu N, Kim R, Guittard GC, Thompson CD, Day PM, Hamm DE, Pang YS, Graham BS, Lowy DR, Schiller JT
Journal of Immunology. 10: 4049, 2019. [ Journal Article ]

Adenovirus vector-based prime-boost vaccination via heterologous routes induces cervicovaginal CD8+ T cell responses against HPV16 oncoproteins

Cuburu N, Khan S, Thompson CD, Kim R, Vellinga J, Zahn R, Lowy DR, Scheper G, Schiller JT
Int J Cancer. 142/7: 1467-1479, 2018. [ Journal Article ]

Explanations for the high potency of HPV prophylactic vaccines

Schiller J, Lowy D
Vaccine. 36/32 Part A: 4768-4773, 2018. [ Journal Article ]

An Infrared Dye-Conjugated Virus-like Particle for the Treatment of Primary Uveal Melanoma

Kines RC, Varsavsky I, Choudhary S, Bhattacharya D, Spring S, McLaughlin R, Kang SJ, Grossniklaus HE, Vavvas D, Monks S, MacDougall JR, de los Pinos E, Schiller JT
Molecular Cancer Therapeutics. 17/2: 565-574, 2018. [ Journal Article ]

Efficient Production of Papillomavirus Gene Delivery Vectors in Defined In Vitro Reactions

Cerqueira C, Thompson CD, Day PM, Pang YS, Lowy DR, Schiller JT
Molecular Therapy. 5: 165-179, 2017. [ Journal Article ]

Job Vacancies

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Team

Postdoctoral Fellow (CRTA)
Nathan Fons, Ph.D.
Special Volunteer
Rhonda C. Kines, Ph.D.
Research Biologist
Cynthia D. Thompson, M.S.
POSTBACCALAUREATE FELLOW (CRTA)
Shiv Sethi, B.S.
Postbaccalaureate Fellow (CRTA)
Mason Garrick Muir, B.A.
Ph.D. candidate (OxCam)
Kritika Singh, B.S.