Patricia Day, Ph.D.

Patricia M. Day, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 37, Room 4112
  • Bethesda, MD 20892-4263
  • 240-760-6480
  • 240-541-4502
Laboratory of Cellular Oncology


My major projects in LCO have involved applying cell biological techniques to questions of papillomavirus entry and early events in infection. In one of my early studies in this area I defined the cellular pathway utilized by papillomaviruses for uptake and intracellular transport during the establishment of infection. In a separate project, I developed an assay to evaluate viral uncoating by assessing antibody accessibility to the carboxyl terminus of L2 and the viral genome.

Areas of Expertise

Virus Trafficking
Virus Assembly
Virus Neutralization


Selected Key Publications

Interferon gamma prevents entry of human papillomavirus 16 via an L2-dependent mechanism

Day PM, Thompson CD, Lowy DR, Schiller JT.
J. Virol. 91(10): e00168-17, 2017. [ Journal Article ]

Involvement of nucleophosmin (NPM1/B23) in assembly of infectious HPV16 capsids

Day PM, Thompson CD, Pang YY, Lowy DR, Schiller JT.
Papillomavirus Res. 1: 74–89, 2015. [ Journal Article ]

The HPV16 and MusPV1 papillomaviruses initially interact with distinct host components on the basement membrane

Day PM, Thompson CD, Lowy DR, Schiller JT.
Virology. 481: 79-94, 2015. [ Journal Article ]

Concepts of papillomavirus entry into host cells

Day PM, Schelhaas M.
Curr Opin Virol. 4: 24-31, 2014. [ Journal Article ]

Identification of a role for the trans-Golgi network in human papillomavirus 16 pseudovirus infection

Day PM, Thompson CD, Schowalter RM, Lowy DR, Schiller JT.
J. Virol. 87: 3862-70, 2013. [ Journal Article ]