Jack F. Shern, M.D.

Jack F. Shern, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Pediatric Oncology Branch


Dr. Jack Shern is a physician scientist within the Pediatric Oncology Branch. His research is focused on defining and developing precision therapies targeting the genetic mutations that drive tumorigenesis. Most recently, his efforts have turned towards using single cell sequencing to discover tumor subclonal populations that are responsible for relapse and refractory disease. He is actively engaged in the Children's Oncology Group, working on pediatric soft tissue sarcomas to investigate the utility of using mutational information as biomarkers for the diagnosis and management of pediatric rhabdomyosarcoma.

Areas of Expertise

Fusion Oncogenes

Information for Patients

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Selected Key Publications

Serial evaluation of CD19 surface expression in pediatric B-cell malignancies following CD19-targeted therapy

Libert D, Yuan CM, Masih KE, Galera P, Salem D, Shalabi H, Yates B, Delbrook C, Shern JF, Fry TJ, Khan J, Stetler-Stevenson M, Shah NN.
Leukemia. [Epub ahead of print], 2020. [ Journal Article ]

Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma

Gryder BE, Pomella S, Sayers C, Wu XS, Song Y, Chiarella AM, Bagchi S, Chou HC, Sinniah RS, Walton A, Wen X, Rota R, Hathaway NA, Zhao K, Chen J, Vakoc CR, Shern JF, Stanton BZ, Khan J.
Nat Genet. 51(12): 1714-22, 2019. [ Journal Article ]

Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Yeung C, Gibson AE, Issaq SH, Oshima N, Baumgart JT, Edessa LD, Rai G, Urban DJ, Johnson MS, Benavides GA, Squadrito GL, Yohe ME, Lei H, Eldridge S, Hamre J 3rd, Dowdy T, Ruiz-Rodado V, Lita A, Mendoza A, Shern JF, Larion M, Helman LJ, Stott GM, Krishna MC, Hall MD, Darley-Usmar V, Neckers LM, Heske CM.
Cancer Res. 79(19): 5060-73, 2019. [ Journal Article ]

Sequential loss of tumor surface antigens following chimeric antigen receptor T-cell therapies in diffuse large B-cell lymphoma

Shalabi H, Kraft IL, Wang HW, Yuan CM, Yates B, Delbrook C, Zimbelman JD, Giller R, Stetler-Stevenson M, Jaffe ES, Lee DW, Shern JF, Fry TJ, Shah NN.
Haematologica. 103(5): e215-e218, 2018. [ Journal Article ]

KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis

Murgai M, Ju W, Eason M, Kline J, Beury DW, Kaczanowska S, Miettinen MM, Kruhlak M, Lei H, Shern JF, Cherepanova OA, Owens GK, Kaplan RN.
Nat Med. 23(10): 1176-90, 2017. [ Journal Article ]

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Clinical Fellow
Thomas Fountaine, M.D.
Special Volunteer
Ira Kraft
Bioinformatics Specialist (Contr.)
Haiyan Lei, Ph.D.
Postdoctoral Fellow (CRTA)
Carly Sayers, Ph.D.