Breadcrumb

Chuong D. Hoang, M.D.

Chuong D. Hoang, M.D., FACS

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Hoang is a surgeon-scientist sub-specialized in thoracic surgical oncology. 

His research section (Molecular Therapeutics) is concerned with the comprehensive identification, understanding of mechanisms, innovating delivery methods, and preclinical development of promising candidate therapeutic microRNAs (miRNA or miR) against thoracic cancers.  This translational research pipeline also serves to generate hypothesis-driven projects aimed at biomarker discovery for purposes of diagnosis, prognosis, and response evaluation. Extensive multi-disciplinary collaborations ranging from computational systems biology to materials science and chemistry have been established to achieve these broad goals.  His lab currently uses malignant pleural mesothelioma, a topologically complex surface cancer involving the chest cavity, as a model to integrate and validate these research endeavors.  Other thoracic cancers such as thymic epithelial tumors and non-small cell lung carcinomas are also of interest with ongoing research project development. 

His clinical expertise includes all the major aspects of thoracic surgery including procedures for lung cancer, other primary lung tumors, mesothelioma, thymic malignancies, esophageal cancer, pulmonary metastases, Pancoast tumors, and tracheal cancers.  He utilizes the latest techniques in endoscopic and minimally-invasive (VATS and robotic) thoracic surgery. 

Areas of Expertise

1) malignant mesothelioma, 2) thymic epithelial tumors, 3) non-small cell lung cancer, 4) thoracic neuroendocrine tumors, 5) esophageal cancer, 6) pulmonary metastatic cancers, 7) minimally invasive thoracic surgery (VATS & RATS), 8) thoracic endoscopy, 9) microRNA

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them. 

Publications

Selected Recent Publications

Surface-fill hydrogel attenuates the oncogenic signature of complex anatomical surface cancer in a single application

Poulami Majumder, Anand Singh, Ziqiu Wang, Kingshuk Dutta, Roma Pahwa, Chen Liang, Caroline Andrews, Nimit L Patel, Junfeng Shi, Natalia de Val, Scott T R Walsh, Albert Byungyun Jeon, Baktiar Karim, Chuong D Hoang, Joel P Schneider.
Nature Nanotechnology. 2021. [ Journal Article ]

MicroRNA-206 suppresses mesothelioma progression via the Ras signaling axis

Anand Singh, Nathanael Pruett, Roma Pahwa, Arushi P Mahajan, David S Schrump, Chuong D Hoang.
Molecular Therapy Nucleic Acids. 24: 669-681, 2021. [ Journal Article ]

Normal mesothelial cell lines newly derived from human pleural biopsy explants

Nathanael Pruett, Anand Singh, Ahjeetha Shankar, David S Schrump, Chuong D Hoang.
American Journal of Physiology Lung Cellular and Molecular Physiology. 319(4): L652-L660, 2020. [ Journal Article ]

MicroRNA-215-5p Treatment Suppresses Mesothelioma Progression via the MDM2-p53-Signaling Axis

Singh A, Bhattacharyya N, Srivastava A, Pruett N, Ripley RT, Schrump DS, Hoang CD
Molecular Therapy. 27(9): 1665-1680, 2019. [ Journal Article ]

Metadherin Is a Prognostic Apoptosis Modulator in Mesothelioma Induced via NF-κB-Mediated Signaling

Zhang L, Singh A, Plaisier C, Pruett N, Ripley RT, Schrump DS, Hoang CD
Translational Oncology. 12(6): 859-870, 2019. [ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Post-doctoral Fellow - Molecular analysis of thoracic malignancy Ph.D. or equivalent Jan Pappas jan.pappas@nih.gov
Staff Scientist - Oncology, molecular biology, RNA biology Ph.D. or equivalent, M.D. or equivalent Jan Pappas jan.pappas@nih.gov

Team

Nurse Practitioner
Debosree Jayaram, C.R.N.P.
Patient Care Coordinator (Contr.)
Jenny Hauprich
Postdoctoral Fellow (Visiting)
Shivani Dixit, Ph.D.
Program Specialist
Jan Pappas
Nurse Practitioner
Cheryl Warga, C.R.N.P.
Research Nurse
Lydiah Mutumbi, RN