Breadcrumb

Anand Singh, Ph.D.

Anand Singh, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Thoracic Surgery Branch

RESEARCH SUMMARY

Dr. Singh’s current research work involves investigating the regulatory networks comprised of interactions among microRNA (miRNA) and transcription factors in order to gain insight into cancer mechanisms and inspire development of novel therapeutic strategies primarily in malignant mesothelioma. MicroRNA epigenetically regulates multiple genes due to partial complementarity to the 3’UTR region of genes and plays important role in cancer initiation and pathogenesis. Most of the MicroRNA expression is tissue specific and based on its function in cancer categorized as tumor suppressor or oncogene (oncomiR). In mesothelioma, unlike other solid tumors mutation burden is very low and development of tumor is driven primarily by the loss of tumor suppressor genes (CDKN2A, NF2, BAP1, P53 etc), rather than by activation of classic driving oncogenes. Dr. Singh’s current focus is to explore the epigenetic regulatory network of mesothelioma pathogenesis and to develop miRNA based loco-regional therapy for the treatment of mesothelioma.

Areas of Expertise

1) malignant pleural mesothelioma 2) cancer epigenetics 3) RNA interference 4) cellular signaling 5) in vivo orthotopic tumor modeling

Publications

Surface-fill Hydrogel Attenuates the Oncogenic Signature of Complex Anatomical Surface Cancer in a Single Application

Poulami Majumder*, Anand Singh*, Ziqiu Wang, Kingshuk Dutta, Roma Pahwa, Chen Liang, Caroline Andrews, Nimit L. Patel, Junfeng Shi, Natalia de Val, Scott T. R. Walsh, Albert Byungyun Jeon, Baktiar Karim, Chuong D. Hoang & Joel P. Schneider (*Equal first author)
Nat Nanotechnol. Online ahead of print: 2021.
Full-Text Article
[ Journal Article ]

MicroRNA-206 suppresses mesothelioma progression via the Ras signaling axis

Anand Singh, Nathanael Pruett, Roma Pahwa, Arushi P Mahajan, David S Schrump, Chuong D Hoang
Molecular Therapy and Nucleic Acids. 24: 669-681, 2021.
Full-Text Article
[ Journal Article ]

MicroRNA-215-5p treatment suppresses mesothelioma progression via the MDM2-p53-signaling axis

Anand Singh, Nisan Bhattacharyya, Abhishek Srivastava, Nathanael Pruett, R Taylor Ripley, David S Schrump, Chuong D Hoang
Molecular Therapy. 27(9): 1665-1680, 2019.
Full-Text Article
[ Journal Article ]

NADPH oxidase 4 modulates hepatic responses to lipopolysaccharide mediated by Toll-like receptor-4

Anand Singh, Bhargav Koduru, Cameron Carlisle, Hasina Akhter, Rui-Ming Liu, Katrin Schroder, Ralf P Brandes, David M Ojcius
Scientific Reports. 7(1): 14346, 2017.
Full-Text Article
[ Journal Article ]

Long-term suppression of HIV-1C virus production in human peripheral blood mononuclear cells by LTR heterochromatization with a short double-stranded RNA

Anand Singh, Jayanth K Palanichamy, Pradeep Ramalingam, Muzaffer A Kassab, Mohita Bhagat, Raiees Andrabi, Kalpana Luthra, Subrata Sinha, Parthaprasad Chattopadhyay
Journal of Antimicrobial Chemotherapy. 69(2): 404-415, 2014.
Full-Text Article
[ Journal Article ]