News and Events

INSPIRED Symposium - Registration Now Open!

Date: March 1, 2023
Location: Building 45, Natcher Auditorium, National Institutes of Health

INSPIRED: Insights in Pediatric CAR T-cell Immunotherapy: Recent Advances and Future Directions

With the primary goal to bring together the expanding pediatric and young adult CAR T-cell community, in addressing major clinical advances achieved over the last decade and outstanding gaps warranting further focus, we aim to reflect on the 10+ year experience of CAR T-cell delivery to pediatric and young adults with B-cell malignancies. Based on experience gained over this time, this conference will focus on highlighting current best practices, opportunities to address unmet needs, and areas where future research is needed or ongoing. Our primary goal for this conference is to allow for cross-fertilization and collaboration as we strive to improve outcomes using CAR T-cell therapy in pediatric cancers.

Online registration information can be found at: https://go.cancer.gov/I2IUxi0
For conference-related questions, please contact ccrconferences@mail.nih.gov

Three-dimensional illustration of a SSHEL drug delivery system.

Researchers create a novel cancer drug delivery system inspired by bacterial spores

CCR researchers, led by Senior Investigator Kumaran S. Ramamurthi, Ph.D., have found a way to deliver drugs directly to cancerous tissue — at least in an animal model — by copying the structure of bacterial spores. Their synthetic, spore-like particles are a novel approach to avoiding the harmful systemic side effects of chemotherapy.

In Memoriam: Ji Ming Wang, M.D., Ph.D. (1950 – 2022)

The CCR mourns the recent passing of colleague and friend Ji Ming Wang, M.D., Ph.D., Senior Investigator and Head of the Chemoattractant Receptor and Signal Section in the Cancer Innovation Laboratory.

Normally, tumor cells evade T cells by expressing a checkpoint protein known as PD-L1 (left). Atezolizumab (Tecentriq) binds to PD-L1 and blocks it from binding to another checkpoint protein, PD-1 (right). This helps T cells regain their ability to kill tumor cells.

NCI clinical trial leads to atezolizumab approval for advanced alveolar soft part sarcoma

NCI and CCR researchers have played an instrumental role in identifying the first treatment approved for advanced alveolar soft part sarcoma. The immunotherapy drug atezolizumab (Tecentriq) was approved by the U.S. Food and Drug Administration for the treatment of adults and children two years of age and older with alveolar soft part sarcoma that has spread to other parts of the body or cannot be removed by surgery. The CCR Pediatric Oncology Branch provided treatment and care for all trial patients under 18 years old, making this the first approval for atezolizumab in children.

Tumor cell community in a hepatocellular carcinoma, a type of liver cancer.

Researchers uncover stable molecular networks inside liver tumors

The ever-changing nature of tumor microenvironments makes treating cancerous tumors difficult. CCR researchers, led by Xin Wei Wang, Ph.D., Deputy Chief of the Laboratory of Human Carcinogenesis, have performed single-cell RNA sequencing analyses on samples from 44 liver cancer patients. They have uncovered stable molecular networks that cells within liver tumors use to speak with nearby immune cells, which could open a path for therapeutic exploration for liver cancer.

Image credit: Marielle E. Yohe, M.D., Ph.D.

Drug Combination Shows Promise for Rhabdomyosarcoma, but Can It Get to Clinical Trials?

A study led by Marielle E. Yohe, M.D., Ph.D., Lasker Clinical Research Scholar in the Laboratory of Cell and Developmental Signaling, and Javed Khan, M.D., Deputy Chief and Senior Investigator in the Genetics Branch, has identified a potential new treatment for children with rhabdomyosarcoma. The researchers are exploring options and hope to test their drug combination in human clinical trials.

Neurons exposed to Ara-C chemotherapy trigger a DNA damage response at enhancers, marked by foci of gamma-H2AX (red) colocalizing with 53BP1 (green).

When chemotherapy interrupts genetic programs critical for neuronal development and activity, cells accrue DNA damage and die

To become neurons, brain cells must damage and immediately repair their own DNA. Some chemotherapies may harm neurons by interfering with this process.

Tumor cells are identified by islands of blue nuclei surrounded by the support cells.

Researchers exploit novel vulnerability to deprive solid tumors of nutrients

Rapidly dividing cancer cells in solid tumors can outgrow their supply of nutrients. New research suggests that tumor support cells produce collagen-derived glutamine as a source of energy for nutrient-deprived tumors. This work reveals a novel approach for designing anti-cancer drugs that can starve solid tumors.

Peter Richman, Estefania E. Marchan and their daughter Rafaela

Removing risk of stomach cancer for her daughter

Stomach cancer remains deadly in the United States despite its rarity. After discovering she was at high risk for the disease, Estefania E. Marchan decided to undergo a total gastrectomy. For a subsequent pregnancy, she ensured her daughter would never face the same risks.

Canva image of female doctor with male patient

Clinical trial researching combination drug therapy for multiple myeloma

A clinical trial led by Elizabeth M. Hill, M.D., Assistant Research Physician in the Lymphoid Malignancies Branch, is researching hematopoietic stem cell transplants and therapy for acute myeloid leukemia.

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