News and Events
Offering “life-sustaining” treatment without compromising quality of life
When Alison James received her diagnosis of squamous cell carcinoma, she was alarmed by the side effects associated with the standard of care. She traveled to the NIH Clinical Center for a CCR clinical trial that offered treatment with less impact to her quality of life.
Read MoreClinical trial researching immunotherapy for lung cancer
David S. Schrump, M.D., M.B.A., FACS, Chief of the Thoracic Surgery Branch, is leading a trial researching immunotherapy for non-small cell lung cancer.
Read MoreClinical trial researching therapy for recurrent respiratory papillomatosis
Scott M. Norberg, D.O., Assistant Research Physician in the Center for Immuno-Oncology, is leading a trial researching drug therapy to reduce necessary surgeries for recurrent respiratory papillomatosis.
Read MoreShining a light on an elusive cancer metabolite
Researchers have long sought a means for subcellular imaging of acetyl-CoA, a metabolite suspected to play a critical role in turning genes on and off. In an important advance, CCR researchers have invented a glowing biosensor to detect the elusive metabolite, paving the way for future studies.
Read MoreSeldom-studied immune cells in the liver may be helpful in treating cancer
CCR researchers have discovered that certain immune cells in the liver, called MAITs, often surround liver tumors but fail to infiltrate them. An analysis suggests that treatment with immune checkpoint inhibitors could potentially trigger these immune cells to help them infiltrate and attack the tumors.
Read MoreClinical trial researches bone marrow transplants for blood cancers
A clinical trial led by Christopher G. Kanakry, M.D., Lasker Clinical Research Scholar in the Center for Immuno-Oncology, is researching bone marrow transplants for some types of blood cancers, such as high-risk leukemia, lymphoma, myelodysplastic syndrome or multiple myeloma.
Read MoreCCR Hosts Communications Course for Healthcare Providers in Oncology
Dedicated transdisciplinary teams of healthcare providers from the CCR’s Clinical Care Programs gathered to learn communication skills centered on essential topics of patient care.
Read MoreChromatin modifier linked to immunotherapy resistance in HPV-negative head and neck cancers
Researchers have discovered that a chromatin-regulating enzyme called SMYD3 limits the access of cancer-attacking immune cells to HPV-negative head and neck cancers, therefore decreasing immunotherapy’s effectiveness. Depleting SMYD3 increased the cancer’s sensitivity to a standard immunotherapy drug in mouse models.
Read MoreNew insights explain how the same protein can serve different functions
Proteins can often choose between potential interacting partners and serve different functions inside cells. How these choices are made is not entirely clear. New research shows that the exact location in a cell where the protein is produced and the rate of its synthesis are key factors in this choice.
Read MoreNew T-cell therapy shrinks solid tumors in early-phase clinical trial
Trial results show that engineered T cells can effectively target mesothelin, a protein found on many solid tumors.
Read MoreStudies of an experimental ovarian cancer therapy identify a biomarker of treatment response
A new biomarker may identify patients who can benefit from drugs that inhibit CHK1 after their ovarian cancer has become resistant to PARP inhibitors.
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