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Giorgio Trinchieri, M.D.

Giorgio Trinchieri, M.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Trinchieri has contributed to the identification of the interplay between inflammation/innate resistance and adaptive immunity, and of the role of cytokines and interferons in the regulation of hematopoiesis, innate resistance and immunity in infections and cancer.  His main focus now is the role of inflammation/innate resistance and commensal microbiota in carcinogenesis, cancer progression and therapy of cancer.

As Chief, Dr. Trinchieri oversees the operations of intramural laboratories that constitute the major immunologic component of the NCI inflammation and cancer initiative that seeks to partner NCI's expertise in inflammation and immunology with its cutting-edge etiology and carcinogenesis program. 

Areas of Expertise

Inflammation
Carcinogenesis
Cytokines
Interleukin-12

Publications

Selected Recent Publications

Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients.

Davar D, Dzutsev AK, McCulloch JA, Rodrigues RR, Chauvin JM, Morrison RM, Deblasio RN, Menna C, Ding Q, Pagliano O, Zidi B, Zhang S, Badger JH, Vetizou M, Cole AM, Fernandes MR, Prescott S, Costa RGF, Balaji AK, Morgun A, Vujkovic-Cvijin I, Wang H, Borhani AA, Schwartz MB, Dubner HM, Ernst SJ, Rose A, Najjar YG, Belkaid Y, Kirkwood JM, Trinchieri G, Zarour HM
Science. 371(6529): 595-602, 2021. [ Journal Article ]

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response.

Spencer CN, McQuade JL, Gopalakrishnan V, McCulloch JA, Vetizou M, Cogdill AP, Khan MAW, Zhang X, White MG, Peterson CB, Wong MC, Morad G, Rodgers T, Badger JH, Helmink BA, Andrews MC, Rodrigues RR, Morgun A, Kim YS, Roszik J, Hoffman KL, Zheng J, Zhou Y, Medik YB, Kahn LM, Johnson S, Hudgens CW, Wani K, Gaudreau PO, Harris AL, Jamal MA, Baruch EN, Perez-Guijarro E, Day CP, Merlino G, Pazdrak B, Lochmann BS, Szczepaniak-Sloane RA, Arora R, Anderson J, Zobniw CM, Posada E, Sirmans E, Simon J, Haydu LE, Burton EM, Wang L, Dang M, Clise-Dwyer K, Schneider S, Chapman T, Anang NAS, Duncan S, Toker J, Malke JC, Glitza IC, Amaria RN, Tawbi HA, Diab A, Wong MK, Patel SP, Woodman SE, Davies MA, Ross MI, Gershenwald JE, Lee JE, Hwu P, Jensen V, Samuels Y, Straussman R, Ajami NJ, Nelson KC, Nezi L, Petrosino JF, Futreal PA, Lazar AJ, Hu J, Jenq RR, Tetzlaff MT, Yan Y, Garrett WS, Huttenhower C, Sharma P, Watowich SS, Allison JP, Cohen L, Trinchieri G, Daniel CR, Wargo JA.
Science. 374(6575): 1632-1640, 2021. [ Journal Article ]

Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1.

McCulloch JA, Davar D, Rodrigues RR, Badger JH, Fang JR, Cole AM, Balaji AK, Vetizou M, Prescott SM, Fernandes MR, Costa RGF, Yuan W, Salcedo R, Bahadiroglu E, Roy S, DeBlasio RN, Morrison RM, Chauvin JM, Ding Q, Zidi B, Lowin A, Chakka S, Gao W, Pagliano O, Ernst SJ, Rose A, Newman NK, Morgun A, Zarour HM, Trinchieri G, Dzutsev AK.
Nat Med.. 28(3): 545-556, 2022. [ Journal Article ]

Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages.

Li Z, Gurung M, Rodrigues RR, Padiadpu J, Newman NK, Manes NP, Pederson JW, Greer RL, Vasquez-Perez S, You H, Hioki KA, Moulton Z, Fel A, De Nardo D, Dzutsev AK, Nita-Lazar A, Trinchieri G, Shulzhenko N, Morgun A.
J Exp Med.. 219(7): 2022. [ Journal Article ]

Targeting the gut microbiota for cancer therapy.

Fernandes MR, Aggarwal P, Costa RGF, Cole AM, Trinchieri G.
Nat Rev Cancer. 22(12): 703-722, 2022. [ Journal Article ]

Job Vacancies

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Team

Technical Laboratory Manager
Sharon Bargo, M.S.
Research Fellow
John McCulloch, Ph.D.
Postdoctoral Fellow (Visiting)
Miriam Rodriguez Fernandes, Ph.D.
Research Associate (Contr.)
April Huang, B.S.
Biological Laboratory Technician
Loretta Smith
Research Collaborator
Soumen Roy, Dr. rer. nat.
Special Volunteer
Stephanie Prescott, M.S.N.
Special Volunteer
Ren-Ming Dai
Special Volunteer
Rodrigo Xavier Das Neves, Ph.D.