Shown below are our existing GEM models. To accommodate the unmet needs of CCR investigators, CAPR will consider importing GEM models and/or alleles (assuming licensing availability) from other institutions and repositories. In addition, CAPR will also consider generating new models if their need is well-justified.
Click on the model type to view detailed information about each model
| Model Type | Genetic Events | Induction | Allograft | |
|---|---|---|---|---|
|
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EGFRL858R/T790M |
Doxycycline | - | |
| KrasG12D/Lkb1; KrasG12D/p53 | AdCre/Lenti-Cre | ✔ | ||
| EML4-ALK | Doxycycline | - | ||
|
Image
|
Glioblastoma | pRB/KrasG12D/PTEN | GFAP-CreER/tam Lenti-Cre |
✔ |
|
Image
|
Serous Ovarian Carcinoma |
pRb/p53c/c or m/- pRb/p53c/c or m/- /Brca1 prb/p53c/c or m/- /Brca2 |
AdCre | ✔ |
|
Image
|
Melanoma | HGF/MET | UV or DMBA | ✔ |
| BRAFV600E | UV, Tyr-Cre | ✔ | ||
|
Image
|
Pancreatic Ductal AdCa |
KrasG12D/p53 | PDX1-Cre |
✔ |
Recently developed models now available: Mammary adenocarcinoma, Neuroblastoma, Peripheral nerve sheath tumor (PNST) and Malignant PNST