The Histopathology team is responsible for model characterization, developing/optimizing methods for biomarker detection, and the quantification of response to drug treatment/resistance.
Team Leader
Laura Bassel, Ph.D., DVM, DACVP, Pathologist
Team Members
Wendi Custer Lawrence, Research Associate II
Maureen Kennedy, Research Associate II
Expertise
- Complete histopathology laboratory for producing H&E, IHC, IFC slides
- Gross necropsy of preclinical models and diagnostic health cases
- Histopathological analysis including model characterization, and disease grading/staging
- Histopathological evaluation of drug toxicity
- Development/optimization of immunohistochemical/immunofluorescent biomarker detection
- Manual semi-quantitative scoring of disease severity and response to drug treatment/resistance
- Automated quantification of drug efficacy/resistance
- Digital slide scanning and archiving
The Animal Resources section is dedicated to breeding and implementing experimental protocols on the transgenic mice that form the foundation for CAPR's preclinical mouse models of human cancer.
Team Leader
Theresa Guerin, Research Associate III, Animal Colony Manager
Team Members
Chelsey Hollar, Research Associate I
Ashleigh Main, Senior Laboratory Animal Technician
Heather Holtzman, Senior Laboratory Animal Technician