Breadcrumb

Center for Advanced Preclinical Research: Histopathology & Animal Research Support

The Histopathology team is responsible for model characterization, developing/optimizing methods for biomarker detection, and the quantification of response to drug treatment/resistance.

Team Leader

Laura Bassel, Ph.D., DVM, DACVP, Pathologist

Team Members

Wendi Custer Lawrence, Research Associate II

Maureen Kennedy, Research Associate II

Expertise

  • Complete histopathology laboratory for producing H&E, IHC, IFC slides
  • Gross necropsy of preclinical models and diagnostic health cases
  • Histopathological analysis including model characterization, and disease grading/staging
  • Histopathological evaluation of drug toxicity
  • Development/optimization of immunohistochemical/immunofluorescent biomarker detection
  • Manual semi-quantitative scoring of disease severity and response to drug treatment/resistance
  • Automated quantification of drug efficacy/resistance
  • Digital slide scanning and archiving

 

The Animal Resources section is dedicated to breeding and implementing experimental protocols on the transgenic mice that form the foundation for CAPR's preclinical mouse models of human cancer.

Team Leader

Theresa Guerin, Research Associate III, Animal Colony Manager

Team Members

Chelsey Hollar, Research Associate I

Ashleigh Main, Senior Laboratory Animal Technician

Heather Holtzman, Senior Laboratory Animal Technician