Jonathan M. Hernandez, M.D.

Jonathan M. Hernandez, M.D.
Investigator

Dr. Jonathan Hernandez is a surgical oncologist and hepatopancreatobiliary surgeon. As a member of the NCI’s Thoracic and GI Oncology Branch, Dr. Hernandez specializes in the treatment of pancreatic tumors and tumors of the liver and bile ducts. His research efforts focus on elucidating the mechanisms through which tumor cells coopt the microenvironment of distant organs to form life-threatening metastases. The goal of Dr. Hernandez’s research program is to provide patients undergoing resection of localized tumor(s) with novel adjunctive therapies to prevent recurrence of their disease at a later time.

 

Areas of Expertise
1) hepatopancreatobiliary oncologic surgery 2) pancreatic cancer 3) liver metastasis 4) cholangiocarcinoma 5) metastatic niche 6) cell biology

Contact Info

Jonathan M. Hernandez, M.D.
Center for Cancer Research
National Cancer Institute
Building 10, Room 4-5760
Bethesda, MD 20892
Ph: 301-827-0327
jonathan.hernandez@nih.gov

Dr. Hernandez’s research program focuses on interrogating the molecular underpinnings of metastatic colonization in order to interrupt the process prior to its completion. This line of investigation corresponds with a critical need in biomedical research, as metastases are the cause of greater than 90% of cancer related deaths. For patients undergoing resection, identifying and targeting the mechanisms that support the survival and outgrowth of latent, disseminated tumor cells holds great promise for the prevention of tumor recurrence. The lab has utilized complex cDNA and CRISPR-Cas9 screens to identify genes that conspire to drive the outgrowth of disseminated tumor cells, which ostensibly appear to be involved in epigenetic reprogramming, compensatory metabolism, and extracellular matrix deposition and remodeling. Current efforts are focused on elucidation of mechanisms and signal transduction pathway involvement for the identified genes of interest, inorder to unveil clinically translatable targets. The lab utilizes multi-photon intravital microscopy in their mechanistic interrogation in order to fully understand and visualize the dynamics of metastatic outgrowth, including the roles of supporting stromal and immune cells.

 

Scientific Focus Areas:
Cancer Biology, Cell Biology
  1. Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, Singh S, Williams C, Soplop N, Uryu K, Pharmer L, King T, Bojmar L, Davies AE, Ararso Y, Zhang T, Zhang H, Hernandez J, Weiss JM, Dumont-Cole VD, Kramer K, Wexler LH, Narendran A, Schwartz GK, Healey JH, Sandstrom P, Labori KJ, Kure EH, Grandgenett PM, Hollingsworth MA, de Sousa M, Kaur S, Jain M, Mallya K, Batra SK, Jarnagin WR, Brady MS, Fodstad O, Muller V, Pantel K, Minn AJ, Bissell MJ, Garcia BA, Kang Y, Rajasekhar VK, Ghajar CM, Matei I, Peinado H, Bromberg J, Lyden D
    Nature. 527(7578): 329-35, 2015. [ Journal Article ]
  2. Costa-Silva B, Aiello NM, Ocean AJ, Singh S, Zhang H, Thakur BK, Becker A, Hoshino A, Mark MT, Molina H, Xiang J, Zhang T, Theilen TM, García-Santos G, Williams C, Ararso Y, Huang Y, Rodrigues G, Shen TL, Labori KJ, Lothe IM, Kure EH, Hernandez J, Doussot A, Ebbesen SH, Grandgenett PM, Hollingsworth MA, Jain M, Mallya K, Batra SK, Jarnagin WR, Schwartz RE, Matei I, Peinado H, Stanger BZ, Bromberg J, Lyden D.
    Nature Cell Biology. 17(6): 816-26, 2015. [ Journal Article ]
  3. Okada T, Sinha S, Esposito I, Schiavon G, López-Lago MA, Su W, Pratilas CA, Abele C, Hernandez JM, Ohara M, Okada M, Viale A, Heguy A, Socci ND, Sapino A, Seshan VE, Long S, Inghirami G, Rosen N, Giancotti FG.
    Nature Cell Biology. 17(1): 81-94, 2015. [ Journal Article ]
  4. Hernandez JM, Tsalatsanis A, Humphries LA, Miladinovic B, Djulbegovic B, Velanovich V.
    Annals of Surgery. 259(6): 1208-14, 2014. [ Journal Article ]
  5. Hernandez J, Mullinax J, Clark W, Toomey P, Villadolid D, Morton C, Ross S, Rosemurgy A
    Annals of Surgery. 250(1): 76-80, 2009. [ Journal Article ]

Dr. Hernandez graduated from medical school with honors from the University of Florida, and completed general surgery training at the University of South Florida. During his residency, Dr. Hernandez spent two years at the Moffitt Cancer Center and Research Institute interrogating molecular diagnostics for liver metastases and miRNA-mediated mechanisms of metastatic spread with the support of NIH funding. Following residency, Dr. Hernandez completed fellowship training in both surgical oncology and hepatopancreatobiliary surgery at Memorial Sloan Kettering Cancer Center. During his fellowships, Dr. Hernandez spent an additional two years in dedicated basic research studying metastatic colonization as a scholar in the Cell Biology Program of the Sloan Kettering Institute supported by NIH funding and a grant from America’s HepatoPancreatoBiliary Association. He was also a visiting investigator in the Cell and Developmental Biology Department of Weill Medical College of Cornell University studying metastatic niche evolution with funding support from the Conquer Cancer Foundation of the American Society of Clinical Oncology. Dr. Hernandez has authored over 50 peer-reviewed publications and has contributed book chapters in numerous authoritative surgical textbooks.

Name Position
Imani Alexander Postbaccalaureate Fellow (CRTA)
Tatiana Beresnev Data Manager (Contr)
Marcia Mulquin R.N. Research Nurse Specialist
Paul Nolen C.S.T. Patient Care Coordinator
Alok Ranjan Ph.D. Postdoctoral Fellow (Visiting)
Yvonne Shutack Data Manager (Contr)
Surajit Sinha Ph.D. Research Fellow