Jonathan M. Hernandez, M.D.
Dr. Jonathan Hernandez is a surgical oncologist and hepatopancreatobiliary surgeon. As a member of the NCI’s Thoracic and GI Oncology Branch, Dr. Hernandez specializes in the treatment of pancreatic tumors and tumors of the liver and bile ducts. His research efforts focus on elucidating the mechanisms through which tumor cells coopt the microenvironment of distant organs to form life-threatening metastases. The goal of Dr. Hernandez’s research program is to provide patients undergoing resection of localized tumor(s) with novel adjunctive therapies to prevent recurrence of their disease at a later time.
American Board of Surgery: General Surgery
American Board of Surgery: Complex General Surgical Oncology
A Single-Arm Phase II Study of Hepatic Artery Infusion Pump Chemotherapy with Floxuridine and Dexamethasone in Combination with Systemic Chemotherapy for Patients with Colorectal Cancer Metastatic to the LiverOpen - Not yet RecruitingNCI Protocol ID NCI-18-C-0024Investigator Jonathan M. Hernandez, M.D.Share this trial: Referral Contacts
Contact Name Phone Number Maureen Connolly 301-435-5613
Dr. Hernandez’s research program focuses on interrogating the molecular underpinnings of metastatic colonization in order to interrupt the process prior to its completion. This line of investigation corresponds with a critical need in biomedical research, as metastases are the cause of greater than 90% of cancer related deaths. For patients undergoing resection, identifying and targeting the mechanisms that support the survival and outgrowth of latent, disseminated tumor cells holds great promise for the prevention of tumor recurrence. The lab has utilized complex cDNA and CRISPR-Cas9 screens to identify genes that conspire to drive the outgrowth of disseminated tumor cells, which ostensibly appear to be involved in epigenetic reprogramming, compensatory metabolism, and extracellular matrix deposition and remodeling. Current efforts are focused on elucidation of mechanisms and signal transduction pathway involvement for the identified genes of interest, to unveil clinically translatable targets. The lab utilizes multi-photon intravital microscopy to mechanistically interrogate and visualize the dynamics of metastatic outgrowth, including the roles of supporting stromal and immune cells. Moreover, the lab has begun pioneering first-ever human tissue models by repurposing perfusion systems to sustain resected tumor-bearing liver and peritoneum for prolonged ex vivo animation. We envision these models will enable us to 1) perform additional screens and validation experiments in human tissue for the first time, 2) personalize investigation of the metastatic cascade by leveraging multi-photon imaging with an individual patient’s tumor cells, which will be dissociated, labelled, and subsequently injected into the perfusate to seed that patient’s metastatic target tissue, and 3) utilized tumor-bearing tissue as a platform for drug discovery and evaluation of novel drug-delivery combinations and platforms, which we think has the potential to transcend multiple disciplines in translational medicine to permit investigations and manipulations not previously possible.
Selected Key Publications
- Nature. 527(7578): 329-35, 2015. [ Journal Article ]
- Nature Cell Biology. 17(6): 816-26, 2015. [ Journal Article ]
- Nature Cell Biology. 17(1): 81-94, 2015. [ Journal Article ]
Defining optimum treatment of patients with pancreatic adenocarcinoma using regret-based decision curve analysis.Annals of Surgery. 259(6): 1208-14, 2014. [ Journal Article ]
Survival after pancreaticoduodenectomy is not improved by extending resections to achieve negative margins.Annals of Surgery. 250(1): 76-80, 2009. [ Journal Article ]
Dr. Hernandez graduated from medical school with honors from the University of Florida, and completed general surgery training at the University of South Florida. During his residency, Dr. Hernandez spent two years at the Moffitt Cancer Center and Research Institute interrogating molecular diagnostics for liver metastases and miRNA-mediated mechanisms of metastatic spread with the support of NIH funding. Following residency, Dr. Hernandez completed fellowship training in both surgical oncology and hepatopancreatobiliary surgery at Memorial Sloan Kettering Cancer Center. During his fellowships, Dr. Hernandez spent an additional two years in dedicated basic research studying metastatic colonization as a scholar in the Cell Biology Program of the Sloan Kettering Institute supported by NIH funding and a grant from America’s HepatoPancreatoBiliary Association. Dr. Hernandez was also a visiting investigator in the Cell and Developmental Biology Department of Weill Medical College of Cornell University studying metastatic niche evolution with funding support from the Conquer Cancer Foundation of the American Society of Clinical Oncology. Dr. Hernandez has authored over 50 peer-reviewed publications and has contributed book chapters in numerous authoritative surgical textbooks.
|Imani Alexander||Postbaccalaureate Fellow (CRTA)|
|Reed Ayabe M.D.||Clinical Fellow|
|Tatiana Beresnev||Data Manager (Contr)|
|Maureen Connolly R.N.||Research Nurse Specialist|
|Joanna Lamot||Administrative Assistant|
|Paul Nolen C.S.T.||Patient Care Coordinator|
|Alok Ranjan Ph.D.||Postdoctoral Fellow (Visiting)|
|Samantha Ruff M.D.||Clinical Fellow|
|Yvonne Shutack||Data Manager (Contr)|
|Surajit Sinha Ph.D.||Research Fellow|
|Michael Wach M.D.||Clinical Fellow|