Stanley Lipkowitz, M.D., Ph.D.

Stanley Lipkowitz, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


My laboratory has two main areas of interest. 1) We study Cbl proteins, a family of ubiquitin ligases that negatively regulate signaling by receptor tyrosine kinases. 2) We investigate induction of apoptosis in breast cancer cells by TRAIL receptor agonists. I am an attending physician in the Women’s Malignancies clinic at NCI and in the Breast Cancer clinic at Walter Reed National Military Medical Center. As Chief, I oversee the laboratory and clinical research in the WMB. Our goal is to integrate laboratory and clinical research findings into mechanism-based, hypothesis-driven clinical trials on patients with breast and gynecological malignancies.

Areas of Expertise

Cbl Proteins
Ubiquitin Ligases
Receptor Tyrosine Kinases

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them. 


Selected Key Publications

In Vitro Ubiquitination Platform Identifies Methyl Ellipticiniums as Ubiquitin Ligase Inhibitors

Wilson BAP, Voeller D, Smith EA, Wamiru A, Goncharova EI, Liu G, Lipkowitz S, O'Keefe BR.
SLAS Discov. 26(7): 870-884, 2021.
Full-Text Article
[ Journal Article ]

ONC201 kills breast cancer cells in vitro by targeting mitochondria.

Greer YE, Porat-Shliom N, Nagashima K, Stuelten C, Crooks D, Koparde VN, Gilbert SF, Islam C, Ubaldini A, Ji Y, Gattinoni L, Soheilian F, Wang X, Hafner M, Shetty J, Tran B, Jailwala P, Cam M, Lang M, Voeller D, Reinhold WC, Rajapakse V, Pommier Y, Weigert R, Linehan WM, Lipkowitz S.
Oncotarget. 9(26): 18454-18479, 2018.
Full-Text Article
[ Journal Article ]

Analysis of breast cancer in young women in the Department of Defense (DOD) database

Zimmer AS, Zhu K, Steeg PS, Wu A, Gatti-Mays ME, Soltani S, Perkins JG, Shao S, Brown D, Georg M, Hu H, Shriver CD, Lipkowitz S.
Breast Cancer Res.. 168(2): 501-511, 2018.
Full-Text Article

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Postdoctoral Fellow (CRTA)
David Wisnewski, Ph.D.
Postdoctoral Fellow (Visiting)
Manjari Kundu Sil, Ph.D.
Research Chemist
Donna M. Voeller
Graduate Student
Yonit Addissie, M.A.
Nurse Practitioner
Britanny Brooke Solarz , R.N., B.S.N.
Research Nurse
Ann McCoy, R.N.
Patient Care Coordinator (Contr.)
Mireya Gomez
Patient Care Coordinator
Jessica Presentacion-Blanco
Branch Secretary
Josselyn White