Dr. Wei Zhang, Ph.D.

Wei Zhang, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Women's Malignancies Branch


Dr. Zhang's current research focuses on mechanistic and translational aspects of general and site-specific cancer metastasis. Specifically, he is interested in the mechanisms by which cancer cells and their microenvironments collectively contribute to the development of brain metastasis of breast cancer, with the ultimate goal of identifying molecules as the "liquid biopsy" for early diagnosis, and the targets for new preventives and therapies.

Areas of Expertise

1) blood-brain barrier 2) blood-tumor barrier 3) cancer epigenetics 4) tumor Immunology 5) liquid biopsy 6) human papillomavirus (HPV)


Selected Recent Publications

Itraconazole Exerts Its Antitumor Effect in Esophageal Cancer by Suppressing the HER2/AKT Signaling Pathway

Wei Zhang, Ankur S Bhagwath, Zeeshan Ramzan, Taylor A Williams, Indhumathy Subramaniyan, Vindhya Edpuganti, Raja Reddy Kallem, Kerry B Dunbar, Peiguo Ding, Ke Gong, Samuel A Geurkink, Muhammad S Beg, James Kim, Qiuyang Zhang, Amyn A Habib, Sung-Hee Choi, Ritu Lapsiwala, Gayathri Bhagwath, Jonathan E Dowell, Shelby D Melton, Chunga Jie, William C Putnam, Thai H Pham, David H Wang
Mol Cancer Ther. 20(10): 1904-1915, 2021.
Full-Text Article

A "Clue" to Improving Liquid Biopsies for Cancer: Microfluidic Multiparametric Exosome Analysis

Wei Zhang, Thai H Pham, David H Wang
Clin Chem. 67(2): 335-337, 2021.
Full-Text Article
[ Journal Article ]

Acidic Bile Salts Induce Epithelial to Mesenchymal Transition via VEGF Signaling in Non-Neoplastic Barrett's Cells

Qiuyang Zhang, Agoston T Agoston, Thai H Pham, Wei Zhang, Xi Zhang, Xiaofang Huo, Sui Peng, Manisha Bajpai, Kiron Das, Robert D Odze, Stuart J Spechler, Rhonda F Souza
Gastroenterology. 156(1): 130-144, 2019.
Full-Text Article
[ Journal Article ]

KLF13 regulates the differentiation-dependent human papollomavirus life cycle in keratinocytes through STAT5 and IL-8

W Zhang, S Hong, K P Maniar, S Cheng, C Jie, A W Rademaker, A M Krensky, C Clayberger
Oncogene. 35(42): 5565-5575, 2016.
Full-Text Article
[ Journal Article ]

Fbw7y-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes

Dong Seok Kim, Wei Zhang, Scott E Millman, Byung Joon Hwang, Seok Joo Kwon, Carol Clayberger, Michele Pagano, Alan M Krensky
Blood. 120(8): 1658-67, 2012.
Full-Text Article