Breadcrumb

Imran Khan, Ph.D.

Imran Khan, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Women's Malignancies Branch

RESEARCH SUMMARY

Dr. Khan's research focuses on breast cancer brain metastases. He uses in vitro models of the blood-brain barrier to determine the molecular pathways mediating drug permeability into the brain and assess its therapeutic potential in multiple mouse models of breast cancer brain metastases. He is also exploring the role of metastasis suppressor gene (NM23) and antibody drug conjugates (ADCs) in targeting breast cancer metastasis.

Areas of Expertise

1) blood-brain barrier 2) blood tumor barrier 3) breast cancer 4) breast cancer brain metastasis 5) antibody drug conjugates (ADC) 6) metastasis suppressor gene

Publications

Selected Recent Publications

Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility, and Metastasis

Imran Khan, Brunilde Gril, Patricia S Steeg
Cancer Res. 79(18): 4689-4702, 2019.
Full-Text Article
[ Journal Article ]

Metastasis suppressor NME1in exosomes or liposomes conveys motility and migration inhibition in breast cancer model systems

Imran Khan, Brunilde Gril, Ayuko Hoshino, Howard H Yang, Maxwell P Lee, Simone Difilippantonio, David C Lyden, Patricia S Steeg
Clin Exp Metastasis. 39(5): 815-831, 2022.
Full-Text Article
[ Journal Article ]

Keeping brain metastases dormant

Imran Khan, Patricia S Steeg
Nat Cancer. 3(1): 3-5, 2022. [ Journal Article ]

HER2 antibody-drug conjugate controls growth of breast cancer brain metastaes in hematogenous xenograft models, with heterogeneous blood-tumor barrier penetration unlinked to a passive marker

Brunilde Gril, Debbie Wei, Alexandra S Zimmer, Christina Robinson, Imran Khan, Simone Difilippantonio, Michael G Overstreet, Patricia S Steeg
Neuro Oncol. 22(11): 1625-1636, 2020. [ Journal Article ]