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Meera Murgai, Ph.D.

Meera Murgai, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Meera Murgai's research centers on perivascular cell plasticity and heterogeneity in the metastatic microenvironment. Most recently, her efforts have focused on employing single cell sequencing, immunofluorescent imaging, and computational methods to elucidate the stromal cell populations that play pro- and anti-tumor roles in pre-metastatic and metastatic microenvironments.

Areas of Expertise

  • Metastasis and pre-metastatic niche
  • Vascular smooth muscle cells, pericytes, and fibroblasts
  • Stem cell niches in development and disease

Publications

Selected Recent Publications

KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis

Murgai M, Ju W, Eason M, Kline J, Beury DW, Kaczanowska S, Miettinen MM, Kruhlak M, Lei H, Shern JF, Cherepanova OA, Owens GK, Kaplan RN.
Nature Medicine. 23(10): 1176-1190, 2017. [ Journal Article ]

Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective

Cherepanova OA, Gomez D, Shankman LS, Swiatlowska P, Williams J, Sarmento OF, Alencar GF, Hess DL, Bevard MH, Greene ES, Murgai M, Turner SD, Geng YJ, Bekiranov S, Connelly JJ, Tomilin A, Owens GK.
Nature Medicine. 22(6): 657-665, 2016. [ Journal Article ]

Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre-metastatic Niche

Giles AJ, Reid CM, Evans JD, Murgai M, Vicioso Y, Highfill SL, Kasai M, Vahdat L, Mackall CL, Lyden D, Wexler L, Kaplan RN.
Cancer Research. 76(6): 1335-1347, 2016. [ Journal Article ]

Physiological, Tumor, and Metastatic Niches: Opportunities and Challenges for Targeting the Tumor Microenvironment

Murgai M, Giles A, Kaplan R.
Critical Reviews in Oncogenesis. 20(3-4): 301-314, 2015. [ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Post-doctoral Fellow - Pericytes, metastatic microenvironment Ph.D. or equivalent Meera Murgai meera.murgai@nih.gov

Team

Pre-doctoral Visiting Fellow (Graduate Student)
Tamara McErlain, M.S.
Postdoctoral Fellow (CRTA)
Emily Summerbell, Ph.D.
Postdoctoral Fellow (CRTA)
Lauren Ziemer, Ph.D.
Postbaccalaureate Fellow (CRTA)
Elizabeth McCulla, B.S.
Postbaccalaureate Fellow (CRTA)
Morgan Glass