James C. Yang, M.D.

James C. Yang, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Surgery Branch


Dr. Yang is involved in the clinical and scientific study of T-cell adoptive therapy and other immunotherapies to treat melanoma and other cancers. He is particularly interested in expanding these modalities to other cancers such as renal, lung and thyroid cancer and is initiating these clinical protocols. His laboratory efforts have concentrated on the development of novel antigen receptors for T-cells with optimized specificity and efficacy in treating cancers.

Areas of Expertise

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them. 


Selected Recent Publications

Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes

Gros A, Tran E, Parkhurst MR, Ilyas S, Pasetto A, Groh EM, Robbins PF, Yossef R, Garcia-Garijo A, Fajardo CA, Prickett TD, Jia L, Gartner JJ, Ray S, Ngo L, Wunderllich JR, Yang JC, Rosenberg SA.
J Clin Invest. 129(11): 4992-5004, 2019. [ Journal Article ]

Mutated RAS: Targeting the "Untargetable" With T Cells

Chatani PD, Yang JC.
Clin Cancer Res. 26(3): 537-44, 2020. [ Journal Article ]

A Phase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus-associated Epithelial Cancers

Stevanovi─ç S, Helman SR, Wunderlich JR, Langhan MM, Doran SL, Kwong MLM, Somerville RPT, Klebanoff CA, Kammula US, Sherry RM, Yang JC, Rosenberg SA, Hinrichs CS.
Clin Cancer Res. 25(5): 1486-93, 2019. [ Journal Article ]

Treatment of Patients With Metastatic Cancer Using a Major Histocompatibility Complex Class II-Restricted T-Cell Receptor Targeting the Cancer Germline Antigen MAGE-A3

Lu YC, Parker LL, Lu T, Zheng Z, Toomey MA, White DE, Yao X, Li YF, Robbins PF, Feldman SA, van der Bruggen P, Klebanoff CA, Goff SL, Sherry RM, Kammula US, Yang JC, Rosenberg SA.
J Clin Oncol. 35(29): 3322-29, 2017. [ Journal Article ]

Treatment of metastatic uveal melanoma with adoptive transfer of tumour-infiltrating lymphocytes: a single-centre, two-stage, single-arm, phase 2 study

Chandran SS, Somerville RPT, Yang JC, Sherry RM, Klebanoff CA, Goff SL, Wunderlich JR, Danforth DN, Zlott D, Paria BC, Sabesan AC, Srivastava AK, Xi L, Pham TH, Raffeld M, White DE, Toomey MA, Rosenberg SA, Kammula US.
Lancet Oncol. 18(6): 792-802, 2017. [ Journal Article ]

Job Vacancies

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Postdoctoral Fellow (CRTA)
Catherine Ade, Ph.D.
Zhiya Yu
Immunotherapy Clinical Fellow
Alexandra (Alex) Gustafson, M.D.


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