Frederic G. Barr, M.D., Ph.D.

Frederic G. Barr, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 10 - Magnuson CC, Room 2S235D
  • Bethesda, MD 20892-1500
  • 301-480-7176


Dr. Barr’s research laboratory uses a multidisciplinary approach involving genomics and bioinformatics along with cell culture and animal models to study recurrent chromosomal alterations, such as translocations and amplification, in cancer. His laboratory focuses on rhabdomyosarcoma, a family of myogenic soft tissue cancers usually occurring in children, to investigate the genetic basis, biological consequences, and therapeutic implications of chromosomal alterations in these cancers. In addition, Dr. Barr works closely with clinicians at the National Cancer Institute and in the Children's Oncology Group (the nationwide multi-institutional group conducting treatment trials for pediatric cancer) to investigate the utility of these recurrent chromosomal alterations as biomarkers for diagnosis and management.

Areas of Expertise


Selected Key Publications

CDK4 amplification reduces sensitivity to CDK4/6 inhibition in fusion-positive rhabdomyosarcoma

Olanich ME, Sun W, Hewitt SM, Abdullaev Z, Pack SD, Barr FG
Clinical Cancer Research. 21: 4947-4959, 2015. [ Journal Article ]

PAX3-FOXO1 is essential for tumour initiation and maintenance but not recurrence in a human myoblast model of rhabdomyosarcoma

Pandey PR, Chatterjee B, Olanich ME, Khan J, Miettinen MM, Hewitt SM, Barr FG
The Journal of Pathology. 241/5: 626-637, 2017. [ Journal Article ]

Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma

Sun W, Chatterjee B, Shern JF, Patidar R, Song Y, Wang Y, Walker RL, Pawel BR, Linardic CM, Houghton P, Hewitt SM, Edelman DC, Khan J, Meltzer PS, Barr FG.
Int J Cancer. 144(11): 2707-17, 2019. [ Journal Article ]

A Fusion Transcription Factor-Driven Cancer Progresses to a Fusion-Independent Relapse via Constitutive Activation of a Downstream Transcriptional Target

Boudjadi S, Pandey PR, Chatterjee B, Nguyen TH, Sun W, Barr FG
Cancer Res.. 81/11: 2930-2942, 2021. [ Journal Article ]

Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-q14 amplification

Nguyen TH, Vemu PS, Hoy GE, Boudjadi S, Chatterjee B, Shern JF, Khan J, Sun W, Barr FG
J Clin Invest.. 131/15: e138022, 2021. [ Journal Article ]

Job Vacancies

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Research Geneticist
Bishwanath Chatterjee, Ph.D.
Postdoctoral Fellow
Anthony Gaeta, Ph.D.
Postbaccalaureate Fellow
Jorge Lopez-Nava
Postdoctoral Fellow (Visiting)
Pawan Kumar Raut, Ph.D.
Postdoctoral Fellow (Visiting)
Shabir Zargar, Ph.D.


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