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Wenyue  Sun, Ph.D.

Wenyue Sun, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Staff Scientist
Laboratory of Pathology

RESEARCH SUMMARY

Dr. Sun's research interest is in the field of cancer genetics, particularly to understand the genetic and epigenetic alterations in rhabdomyosarcoma, a common pediatric soft tissue tumor. He has characterized the different DNA methylation patterns in rhabdomyosarcoma, and is currently unraveling the functional and clinical significance of these patterns in rhabdomyosarcoma. He systematically investigated the genetic, epigenetic and mitochondrial DNA alterations in head and neck cancer prior to joining the NCI. Dr. Sun has broad experiences on computational analysis of genomic big data.

Areas of Expertise

Rhabdomyosarcoma
Gene Mutation
DNA Methylation
Computational Biology

Publications

Selected Publications

Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma.

Sun W, Chatterjee B, Shern JF, Patidar R, Song Y, Wang Y, Walker RL, Pawel BR, Linardic CM, Houghton P, Hewitt SM, Edelman DC, Khan J, Meltzer PS, Barr FG.
International Journal of Cancer. 144: 2707-17, 2019. [ Journal Article ]

Distinct methylation profiles characterize fusion-positive and fusion-negative rhabdomyosarcoma

Sun W, Chatterjee B, Wang Y, Stevenson HS, Edelman DC, Meltzer PS, Barr FG.
Modern Pathology. 28: 1214-24, 2015. [ Journal Article ]

Novel insight into mutational landscape of head and neck squamous cell carcinoma

Gaykalova DA, Mambo E, Choudhary A, Houghton J, Buddavarapu K, Sanford T, Darden W, Adai A, Hadd A, Latham G, Danilova LV, Bishop J, Li RJ, Westra WH, Hennessey P, Koch WM, Ochs MF, Califano JA, Sun W.
PLoS ONE. 9: e93102, 2014. [ Journal Article ]

Activation of the NOTCH pathway in head and neck cancer

Sun W, Gaykalova DA, Ochs MF, Mambo E, Arnaoutakis D, Liu Y, Loyo M, Agrawal N, Howard J, Li R, Ahn S, Fertig E, Sidransky D, Houghton J, Buddavarapu K, Sanford T, Choudhary A, Darden W, Adai A, Latham G, Bishop J, Sharma R, Westra WH, Hennessey P, Chung CH, Califano JA.
Cancer Research. 74: 1091-104, 2014. [ Journal Article ]

Detection of TIMP3 promoter hypermethylation in salivary rinse as an independent predictor of local recurrence-free survival in head and neck cancer

Sun W, Zaboli D, Wang H, Liu Y, Arnaoutakis D, Khan T, Khan Z, Koch WM, Califano JA.
Clinical Cancer Research. 18: 1082-91, 2012. [ Journal Article ]