Breadcrumb

Dr. Citrin

Deborah E. Citrin, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Radiation Oncology Branch

RESEARCH SUMMARY

Dr. Citrin is a clinician and translational researcher in the Radiation Oncology Branch at the National Cancer Institute. Dr. Citrin’s clinical and laboratory research focus on two main themes:  1) predicting which tumors are resistant to killing by radiation, and in turn, targeting these tumors more effectively with novel drug radiation combinations, and 2) understanding the mechanisms of normal tissue injury from radiation. Dr. Citrin is particularly interested in developing strategies to enhance the capacity of radiation to kill tumor cells while protecting normal tissue from the side effects of radiation treatment. Much of her laboratory work has focused on aging in tissue exposed to radiation through stem cell senescence.

Dr. Citrin leads the Prostate Radiotherapy program at the National Cancer Institute.  She is involved in the clinical care of patients with genitourinary cancers (prostate and bladder), gastrointestinal cancers, and thoracic malignancies. Dr. Citrin is board certified by the American Board of Radiology.

Areas of Expertise

1) prostate cancer 2) brachytherapy 3) stereotactic body radiation therapy (SBRT) / stereotactic ablative radiotherapy (SABR) 4) recurrent prostate cancer 5) normal tissue radiobiology

Information for Patients

Learn more about the Radiation Oncology Prostate Cancer Clinical Research Team and clinical trials.

Publications

Selected Key Publications

Senescence-associated tumor growth is promoted by 12-Lipoxygenase.

Patil S, Reedy JL, Scroggins BT, White AO, Kwon S, Shankavaram U, López-Coral A, Chung EJ, Citrin DE.
Aging. 14(3): 1068-1086, 2022. [ Journal Article ]

Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect

Scroggins BT, Matsuo M, White AO, Saito K, Munasinghe JP, Sourbier C, Yamamoto K, Diaz V, Takakusagi Y, Ichikawa K, Mitchell JB, Krishna MC, Citrin DE
Clin Cancer Res. 24(13): 3137-48, 2018. [ Journal Article ]

IGF-1 Receptor Signaling Regulates Type II Pneumocyte Senescence and Resulting Macrophage Polarization in Lung Fibrosis.

Chung EJ, Kwon S, Reedy JL, White AO, Song JS, Hwang I, Chung JY, Ylaya K, Hewitt SM, Citrin DE.
Int J Radiat Oncol Biol Phys. 110(2): 526-538, 2021.

Detection of failure patterns using advanced imaging in patients with biochemical recurrence following low-dose-rate brachytherapy for prostate cancer

Salerno KE, Turkbey B, Lindenberg L, Mena E, Schott EE, Brennan AK, Roy S, Shankavaram U, Patel K, Cooley-Zgela T, McKinney Y, Wood BJ, Pinto PA, Choyke P, Citrin DE.
Brachytherapy. 2022.
Full-Text Article

12-Lipoxygenase is a Critical Mediator of Type II Pneumocyte Senescence, Macrophage Polarization and Pulmonary Fibrosis after Irradiation

Chung EJ, Reedy JL, Kwon S, Patil S, Valle L, White AO, Citrin DE.
Radiat Res. 192(4): 367-379, 2019.

Job Vacancies

Position Degree Required Contact Name Contact Email
Post-doctoral Fellow - Proteasome, drug development, solid tumor Ph.D. or equivalent Deborah Citrin citrind@mail.nih.gov