Deborah E. Citrin, M.D.
- Center for Cancer Research
- National Cancer Institute
- Building 10 - Hatfield CRC, Room B2-3500
- Bethesda, MD 20892
- 301-496-5457
- citrind@mail.nih.gov
RESEARCH SUMMARY
Dr. Citrin’s clinical and laboratory research in the Radiation Oncology Branch focuses on identifying and targeting mechanisms and modifiers of radiation resistance and radiation toxicity.
Dr. Citrin leads the Prostate Radiotherapy program at the National Cancer Institute. She is involved in the clinical care of patients with genitourinary cancers (prostate and bladder). Dr. Citrin is board certified by the American Board of Radiology.
Areas of Expertise
Information for Patients
Learn more about the Radiation Oncology Prostate Cancer Clinical Research Team and clinical trials.
Deborah E. Citrin, M.D.
Clinical Trials
Research
Dr. Citrin’s clinical and laboratory research focus on two main themes: 1) predicting which tumors are resistant to killing by radiation, and in turn, targeting these tumors more effectively with novel drug radiation combinations, and 2) understanding the mechanisms of normal tissue injury from radiation. Dr. Citrin is particularly interested in developing strategies to enhance the capacity of radiation to kill tumor cells while protecting normal tissue from the side effects of radiation treatment. Much of her laboratory work has focused on aging in tissue exposed to radiation through stem cell senescence.
Publications
Senescence-associated tumor growth is promoted by 12-Lipoxygenase.
Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect
IGF-1 Receptor Signaling Regulates Type II Pneumocyte Senescence and Resulting Macrophage Polarization in Lung Fibrosis.
12-Lipoxygenase is a Critical Mediator of Type II Pneumocyte Senescence, Macrophage Polarization and Pulmonary Fibrosis after Irradiation
Biography
Deborah E. Citrin, M.D.
Dr. Citrin received an M.D. from Duke University, where she also participated in the Howard Hughes Medical Student Research Fellow Program. She completed an internship in Internal Medicine at Washington Hospital Center and completed her residency training at the National Cancer Institute. She is board certified in Radiation Oncology by the American Board of Radiology.
Her career trajectory at NCI involved roles as a staff clinician, as CCR’s first Assistant Clinical Investigator, and as a Tenure-Track Investigator. She joined the Radiation Oncology Branch in 2005 as a staff clinician, became a tenure track investigator in 2007, and received NIH tenure in 2015. In addition to her service as a CCR Deputy Director, Dr. Citrin has held many leadership roles over her career including as an NIH and CCR Women Scientist Advisor, Chair of the CCR Clinical Promotion Review Panel and Vice Chair of the CCR Tenure Review Panel. Among her many accomplishments, she has received the NCI Director’s Emerging Leader Award (2018), the NIH Director’s Alan S. Rabson Award for Clinical Care (2016), and the NIH Director’s Ruth L. Kirschstein Mentoring Award (2023).
Dr. Citrin was named Scientific Director for Clinical Research in CCR in 2024.
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