Breadcrumb

Curtis C. Harris, M.D.

Curtis C. Harris, M.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

We are investigating connections between inflammation, microRNAs, metabolome, microbiome and cancer using a precision medicine strategy. Molecular mechanisms of microRNAs and cytokines associated with human cancer diagnosis, prognosis, and therapeutic outcomes are being investigated. Gene-environment interaction is a seminal concept in the molecular epidemiology of human cancer; our ongoing studies include lung, colon and esophageal cancer. Cellular senescence is a tumor suppressive mechanism that can be activated by p53. We are focused on both the integrative p53 and microRNA networks in tumor suppression and the functional role of p53 isoforms, as natural regulators of cellular senescence and stem cell biology and their dysregulation in cancer and aging.

Areas of Expertise

1) precision medicine of cancer 2) biomarkers of cancer 3) molecular epidemiology 4) p53 function in cancer and aging 5) cancer metabolome 6) cancer microbiome

Publications

Selected Recent Publications

Radiation-induced astrocyte senescence is rescued by Δ133p53

Turnquist C, Beck JA, Horikawa I, Obiorah IE, Von Muhlinen N, Vojtesek B, Lane DP, Grunseich C, Chahine JJ, Ames HM, Smart DD, Harris BT, Harris CC.
Neuro Oncol. 21(4): 474-85, 2019. [ Journal Article ]

Interaction between the microbiome and TP53 in human lung cancer.

Greathouse KL, White JR, Vargas AJ, Bliskovsky VV, Beck JA, von Muhlinen N, Polley EC, Bowman ED, Khan MA, Robles AI, Cooks T, Ryan BM, Padgett N, Dzutsev AH, Trinchieri G, Pineda MA, Bilke S, Meltzer PS, Hokenstad AN, Stickrod TM, Walther-Antonio MR, Earl JP, Mell JC, Krol JE, Balashov SV, Bhat AS, Ehrlich GD, Valm A, Deming C, Conlan S, Oh J, Segre JA, Harris CC.
Genome Bio. 19(1): 123, 2018. [ Journal Article ]

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246.

Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris C.C
Nat Commun. 9(1): 771, 2018. [ Journal Article ]

p53 isoforms regulate premature aging in human cells

von Muhlinen N, Horikawa I, Alam F, Isogaya K, Lissa D, Vojtesek B, Lane DP, Harris CC.
Oncogene. 37(18): 2379-93, 2018. [ Journal Article ]

Identification of a functional SNP in the 3'UTR of CXCR2 that is associated with reduced risk of lung cancer

Ryan BM, Robles AI, McClary AC, Haznadar M, Bowman ED, Pine SR, Brown D, Khan M, Shiraishi K, Kohno T, Okayama H, Modali R, Yokota J, Harris CC.
Cancer Res. 75(3): 566-75, 2015. [ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Tenure-eligible Principal Investigator - Health Disparities Program Leader Ph.D. or equivalent, M.D. or equivalent Lori Holliday hollidal@mail.nih.gov

Team

Postdoctoral Fellow (CRTA)
Jessica Beck, Ph.D.
Research Chemist
Elise Bowman, M.S.
Predoctoral Fellow (Graduate Student)
Leandro Cruz Hermida
Postdoctoral Fellow (CRTA)
Sebastien Jo, Ph.D.
Research Biologist
Mohammed Khan, B.S.
Postdoctoral Fellow (Visiting)
Delphine Lissa, Ph.D.
Special Volunteer
Masaru Matsumoto, Ph.D.
Postdoctoral Fellow (Visiting)
Daxeshkumar Patel, Ph.D.
Postdoctoral Fellow (CRTA)
Joshua Stone, Ph.D.
Special Volunteer
Snorri Thorgeirsson, M.D., Ph.D.
Postbaccalaureate Fellow (CRTA)
Kyra Ungerleider, B.S.
Postdoctoral Fellow (Visiting)
Natalia von Muhlinen, Ph.D.
Postdoctoral Fellow (Visiting)
Chenran Zhang, Ph.D.