Izumi  Horikawa, M.D., Ph.D.

Izumi Horikawa, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Horikawa focuses on cancer and aging research, with a special interest in telomeres, cellular senescence, microRNA and p53.

Areas of Expertise



Selected Recent Publications

Radiation-induced astrocyte senescence is rescued by Δ133p53

Turnquist C, Beck JA, Horikawa I, Obiorah IE, Von Muhlinen N, Vojtesek B, Lane DP, Grunseich C, Chahine JJ, Ames HM, Smart DD, Harris BT, Harris CC.
Neuro Oncol. 21(4): 474-485, 2019. [ Journal Article ]

Δ133p53α, a natural p53 isoform, contributes to conditional reprogramming and long-term proliferation of primary epithelial cells

Mondal AM, Zhou H, Horikawa I, Suprynowicz FA, Li G, Dakic A, Rosenthal B, Ye L, Harris CC, Schlegel R, Liu X.
Cell Death Dis. 9(7): 750, 2018. [ Journal Article ]

p53 isoforms regulate premature aging in human cells

von Muhlinen N, Horikawa I, Alam F, Isogaya K, Lissa D, Vojtesek B, Lane DP, Harris CC
Oncogene. 37(18): 2379-2393, 2018. [ Journal Article ]

Δ133p53: A p53 isoform enriched in human pluripotent stem cells

Horikawa I, Harris CC.
Cell Cycle. 16(18): 1631-1632, 2017. [ Journal Article ]

Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells

Horikawa I, Park KY, Isogaya K, Hiyoshi Y, Li H, Anami K, Robles AI, Mondal AM, Fujita K, Serrano M, Harris CC.
Cell Death Differ. 24(6): 1017-1028, 2017. [ Journal Article ]