![Izumi Horikawa, M.D., Ph.D.](/sites/default/files/styles/sixth_1_1/public/staff-profile-images/horikawa-izumi.jpg?h=22ce1306&itok=rMZ8oJDK)
Izumi Horikawa, M.D., Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Bldg 37, Rm 3054
- Bethesda, MD 20892
- 240-760-7775
- horikawi@mail.nih.gov
RESEARCH SUMMARY
Dr. Horikawa focuses on cancer and aging research, with a special interest in telomeres, cellular senescence, microRNA and p53.Areas of Expertise
Telomeres
MicroRNA
![Izumi Horikawa, M.D., Ph.D.](/sites/default/files/styles/sixth_1_1/public/staff-profile-images/horikawa-izumi.jpg?h=22ce1306&itok=rMZ8oJDK)
Izumi Horikawa, M.D., Ph.D.
Research
Cancer and aging research, with special interest in telomeres, cellular senescence, microRNA and p53
Publications
Selected Recent Publications
Radiation-induced astrocyte senescence is rescued by Δ133p53
Neuro Oncol.
21(4):
474-485,
2019.
[ Journal Article ]
Δ133p53α, a natural p53 isoform, contributes to conditional reprogramming and long-term proliferation of primary epithelial cells
Cell Death Dis.
9(7):
750,
2018.
[ Journal Article ]
p53 isoforms regulate premature aging in human cells
Oncogene.
37(18):
2379-2393,
2018.
[ Journal Article ]
Δ133p53: A p53 isoform enriched in human pluripotent stem cells
Cell Cycle.
16(18):
1631-1632,
2017.
[ Journal Article ]
Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells
Cell Death Differ.
24(6):
1017-1028,
2017.
[ Journal Article ]
Biography
![Izumi Horikawa, M.D., Ph.D.](https://ccr.cancer.gov/sites/default/files/staff-profile-images/horikawa-izumi.jpg)
Staff Scientist
Izumi Horikawa, M.D., Ph.D.
1995 Postdoctoral fellow, NIEHS, Research Triangle Park, NC 1999 Research fellow, NIEHS, Research Triangle Park, NC 2002 Staff Scientist, CCR, NCI, Bethesda, MD