Deborah E. Citrin, M.D.

Deborah E. Citrin, M.D.
Senior Investigator
Radiation Oncology Branch
CCR Deputy Director

Dr. Citrin is a clinician and translational researcher in the Radiation Oncology Branch at NCI. She is a graduate of the Duke University School of Medicine and completed her residency training at the NCI. She is currently a Senior Investigator in the Radiation Oncology Branch. Her research interests include understanding how certain tumors can be resistant to cell killing by radiation and understanding the mechanisms of normal tissue injury from radiation. Dr. Citrin is particularly interested in developing strategies to enhance the capacity of radiation to kill tumor cells while protecting normal tissue from the side effects of radiation treatment. Much of her laboratory work has focused on aging in tissue exposed to radiation through stem cell senescence.

Dr. Citrin is involved in the clinical care of patients with genitourinary cancers (prostate and bladder), gastrointestinal cancers, and thoracic malignancies. Dr. Citrin is board certified by the American Board of Radiology.

Areas of Expertise

1) prostate cancer, 2) bladder cancer, 3) gastrointestinal (GI) cancer, 4) radiation normal tissue injury, 5) radiation fibrosis, 6) radiation modifiers

Contact Info

Deborah E. Citrin, M.D.
Center for Cancer Research
National Cancer Institute
Building 10 - Hatfield CRC, Room B2-3500
Bethesda, MD 20892
Ph: 301-496-5457
citrind@mail.nih.gov

Dr. Citrin's research interests include the pre-clinical and clinical testing of radiation modifiers and the mechanisms of normal tissue injury from radiation. Dr. Citrin is involved in the clinical care of patients with genitourinary cancers (prostate and bladder), gastrointestinal cancers, and melanoma.

Dr. Citrin's group 2018

NIH Scientific Focus Areas:
Cancer Biology, Cell Biology, Clinical Research, Molecular Biology and Biochemistry, Stem Cell Biology
View Dr. Citrin's PubMed Summary.

Selected Key Publications

  1. Short-Term Screening Assays for the Identification of Therapeutics for Cancer..
    Citrin DE.
  2. Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma..
    Goff SL, Dudley ME, Citrin DE, Somerville RP, Wunderlich JR, Danforth DN, Zlott DA, Yang JC, Sherry RM, Kammula US, Klebanoff CA, Hughes MS, Restifo NP, Langhan MM, Shelton TE, Lu L, Kwong ML, Ilyas S, Klemen ND, Payabyab EC, Morton KE, Toomey MA, Steinberg SM, White DE, Rosenberg SA.
  3. Truncated Plasminogen Activator Inhibitor-1 Protein Protects From Pulmonary Fibrosis Mediated by Irradiation in a Murine Model..
    Chung EJ, McKay-Corkum G, Chung S, White A, Scroggins BT, Mitchell JB, Mulligan-Kehoe MJ, Citrin D.
  4. Role of type II pneumocyte senescence in radiation-induced lung fibrosis.
    Citrin DE, Shankavaram U, Horton JA, Shield W 3rd, Zhao S, Asano H, White A, Sowers A, Thetford A, Chung EJ
    J Natl Cancer Inst. 105(19): 1474-84, 2013. [ Journal Article ]
  5. Mesenchymal stem cells inhibit cutaneous radiation-induced fibrosis by suppressing chronic inflammation.
    Horton JA, Hudak KE, Chung EJ, White AO, Scroggins BT, Burkeen JF, Citrin DE
    Stem Cells. 31(10): 2231-41, 2013. [ Journal Article ]

Dr. Citrin is a clinician and translational researcher in the Radiation Oncology Branch at NCI. She is a graduate of the Duke University School of Medicine and completed her residency training at NCI and the National Capital Consortium. She joined the NIH in 2001. Her research interests include the pre-clinical and clinical testing of radiation modifiers and the mechanisms of normal tissue injury from radiation. Dr. Citrin is involved in the clinical care of patients with genitourinary cancers (prostate and bladder) and gastrointestinal cancers. Dr. Citrin is board certified by the American Board of Radiology.

Name Position
Eunjoo S. Chung Ph.D. Staff Scientist
Seokjoo Kwon Ph.D. Biologist (Contr)
Shilpa Patil Ph.D. Postdoctoral Fellow (CRTA)
Jessica Reedy Ph.D. Postdoctoral Fellow (CRTA)
Brad T. Scroggins Ph.D. Research Fellow
Ayla O. White Laboratory Technician (Contr)
Hong Zhang Ph.D. Biologist