Mark Roschewski, M.D.
Dr. Roschewski is a Senior Clinician and the Clinical Director of the Lymphoid Malignancies Branch (LYMB) of the Center for Cancer Research. His research team focuses on the management of aggressive B-cell lymphomas including diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), mantle cell lymphoma (MCL), and primary CNS lymphomas (PCNSL). Recent studies from NCI show that dose-adjusted EPOCH-R is highly effective for adults with BL and specific subtypes of DLBCL, such as primary mediastinal B-cell lymphoma. The LYMB research team also recently demonstrated that targeted agents such as ibrutinib are highly effective when combined with chemotherapy in relapsed and refractory PCNSL. Dr. Roschewski has also pioneered an active translational program focused on studying clonal evolution in follicular lymphoma (FL) with an aim of identifying the molecular biology of FL patients who are failed by current chemotherapy. The FL translational program in the LYMB has multiple clinical studies of targeted agents for FL patients who do not yet require therapy as well as multiple treatment studies for patients in need of frontline or relapsed therapy. An important research focus of the LYMB research team involves developing more effective non-invasive methods of monitoring disease activity in patients with lymphoma, including minimal residual disease assays such as circulating tumor DNA. The LYMB research team also is dedicated to developing novel therapies for patients with rare lymphoma subtypes including EBV-associated lymphomas and rare lymphomas that secondarily involve the CNS.
1) biology and management of FL, 2) clinical applications of circulating tumor DNA (ctDNA) in lymphoma, 3) management of aggressive lymphomas including PCNSL, DLBCL, BL, MCL, and EBV-associated lymphomas
Multicenter Study of Risk-Adapted Therapy With Dose-Adjusted EPOCH-R in Adults With Untreated Burkitt Lymphoma.J Clin Oncol. JCO2000303, 2020. [ Journal Article ]
Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma.Nat Med. 26(2): 270-80, 2020. [ Journal Article ]
Dose-adjusted EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab) in untreated aggressive diffuse large B-cell lymphoma with MYC rearrangement: a prospective, multicentre, single-arm phase 2 study.Lancet Haematol. 5(12): e609-e617, 2018. [ Journal Article ]
- New Engl J Med. 379(18): 1711-21, 2018. [ Journal Article ]
End-of-treatment and serial PET imaging in primary mediastinal B-cell lymphoma following dose-adjusted EPOCH-R: a paradigm shift in clinical decision making.Haematologica. 103(8): 1337-44, 2018. [ Journal Article ]
Dr. Mark Roschewski received his B.A. from the University of Notre Dame in 1997 and his M.D. from the University of Nebraska Medical Center in Omaha in 2001. He completed internal medicine residency training while serving in the U.S. Army and completed his hematology-oncology fellowship in 2009 at Walter Reed Army Medical Center (WRAMC) in Washington, DC. He served as the Director of Hematologic Diseases at WRAMC for 3 years before joining the NIH as a Commissioned Corps officer in the United States Public Health Service in 2013. Dr. Roschewski's current role is as a Senior Clinician in the Lymphoid Malignancies Branch with a clinical research focus on the biology and management of patients with both indolent and aggressive forms of non-Hodgkin's lymphoma.
|Lydia Chou C.R.N.P.||Nurse Practitioner|
|Candis Morrison N.P.||Clinical Collaborator|
|Saleema Osman||Patient Care Coordinator (Contr.)|