Jennifer N. Brudno, M.D.

Jennifer N. Brudno, M.D.
Associate Research Physician

Team Member of:

Dr. Brudno researches the use of chimeric antigen receptor (CAR) T-cell therapy to treat cancers of the blood, including Non-Hodgkin lymphoma, Hodgkin lymphoma, acute lymphoblastic leukemia (ALL), and multiple myeloma. Her focus is in the development of phase I clinical trials. She is also interested in patient safety, particularly in optimizing patient safety for cellular immunotherapies.

Areas of Expertise

1) Hodgkin and Non-Hodgkin lymphoma, 2) multiple myeloma, 3) chimeric antigen receptor (CAR) T-cell therapy, 4) toxicities of immunotherapy

Contact Info

Jennifer N. Brudno, M.D.
Center for Cancer Research
National Cancer Institute
Building 10, Suite 3-3330
Bethesda, Maryland 20892
Ph: 240-858-3213

Dr. Brudno conducts clinical trials to investigate new therapies for hematologic malignancies. Her focus is in the development and execution of clinical trials of chimeric antigen receptor (CAR) T-cell therapy.

NIH Scientific Focus Areas:
Clinical Research, Immunology

Selected Key Publications

  1. Brudno JN, Maric I, Hartman SD, Rose JJ, Wang M, Lam N, Stetler-Stevenson M, Salem D, Yuan C, Pavletic S, Kanakry JA, Ali SA, Mikkilineni L, Feldman SA, Stroncek DF, Hansen BG, Lawrence J, Patel R, Hakim F, Gress RE, Kochenderfer JN.
    J Clin Oncol. 36(22): 2267-2280, 2018. [ Journal Article ]
  2. Brudno JN, Kochenderfer JN.
    Nat Rev Clin Oncol. 15(1): 31-36, 2018. [ Journal Article ]
  3. Brudno JN, Kochenderfer JN.
    Blood. 127(26): 3321-3330, 2016. [ Journal Article ]
  4. Brudno JN, Somerville RP, Shi V, Rose JJ, Halverson DC, Fowler DH, Gea-Banacloche JC, Pavletic SZ, Hickstein DD, Lu TL, Feldman SA, Iwamoto AT, Kurlander R, Maric I, Goy A, Hansen BG, Wilder JS, Blacklock-Schuver B, Hakim FT, Rosenberg SA, Gress RE, Kochenderfer JN.
    J Clin Oncol. 34(10): 1112-1121, 2016. [ Journal Article ]
  5. Brudno J, Tadmor T, Pittaluga S, Nicolae A, Polliack A, Dunleavy K.
    Blood. 127(8): 965-970, 2016. [ Journal Article ]

Dr. Brudno received her Bachelor of Arts from Princeton University and her M.D. from the Emory University School of Medicine. While in medical school, she participated in the NIH Clinical Research Training Program (CRTP), during which she worked with Dr. Neal Young in the National Heart, Lung, and Blood Institute. She completed her medical residency in internal medicine at the Johns Hopkins University School of Medicine. She then completed fellowship training in medical oncology and hematology through the National Cancer Institute and the National Heart, Lung, and Blood Institute. After fellowship training, she joined the research group of Dr. James Kochenderfer in the Experimental Transplantation and Immunology Branch. 

Dr. Brudno is board certified in internal medicine, hematology, and medical oncology.