Tatiana S. Karpova, Ph.D.

Tatiana S. Karpova, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Karpova manages the NCI Optical Microscopy Core. This facility specializes in live imaging, image deconvolution and microscopy quantification methods such as FRET and FRAP. Dr. Karpova conducts research focusing on the regulation of gene expression by chromatin remodelers by observing protein interaction in vivo in live yeast cells. Her research interests include: -the intracellular dynamics of chromatin remodelers, transcriptional activators and co-activators; and -the role of nuclear localization on gene expression as observed in live yeast cells by microscopy.

Areas of Expertise

1) fluorescence imaging


Selected Publications

Dynamic interactions of a transcription factor with DNA are accelerated by a chromatin remodeler

Karpova TS, Chen TY, Sprague BL, McNally JG.
EMBO Rep.. 5: 1064-1070, 2004. [ Journal Article ]

Concurrent fast and slow cycling of a transcriptional activator at an endogenous promoter

Karpova TS, Kim MJ, Spriet C, Nalley K, Stasevich TJ, Kherrouche Z, Heliot L, McNally JG.
Science. 319: 466-469, 2008. [ Journal Article ]

Measuring chromatin interaction dynamics on the second time scale at single-copy genes

Poorey K, Viswanathan R, Carver MN, Karpova TS, Cirimotich SM, McNally JG, Bekiranov S, Auble DT.
Science. 342: 369-72, 2013. [ Journal Article ]

Single Molecule Tracking Of Ace1p In Saccharomyces cerevisiae Defines A Characteristic Residence Time For Non-specific Interactions Of Transcription Factors With Chromatin

Ball DA, Mehta GD, Salomon-Kent,R., Mazza D, Morisaki T, Mueller F, McNally JG, Karpova TS
Nucleic Acids Res. 44: e160, 2016. [ Journal Article ]

Single-Molecule analysis reveals linked cycles of RSC chromatin remodeling and Ace1p transcription factor binding in yeast

Mehta GD, Ball DA, Eriksson PR, Chereji RV, Clark DJ, McNally JG, Karpova TS
Molecular Cell. 72: 875-887, 2018. [ Journal Article ]