David A. Ball, Ph.D.

David A. Ball, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Ball is a Staff Scientist in the Optical Microscopy Core (OMC) which specializes in live-cell imaging, and quantitative biophysical methods. His primary role is to develop and maintain custom microscopes and train investigators on their use. Dr. Ball’s research interests include the development of custom microscopes, software and models to extract and interpret biophysical parameters in cellular processes.

Areas of Expertise

1) single-molecule tracking 2) fluorescence imaging 3) microscope development 4) image analysis 5) stochastic modeling


Selected Recent Publications

Single-molecule analysis of steroid receptor and cofactor action in living cells

V Paakinaho, DM Presman, DA Ball, TA Johnson, RL Schiltz, P Levitt, D Mazza, T Morisaki, TS Karpova, and GL Hager
Nat Commun. 8: 15896, 2017. [ Journal Article ]

Quantifying transcription factor binding dynamics at the single-molecule level in live cells

DM Presman, DA Ball, V Paakinaho, JB Grimm, LD Lavis, TS Karpova, and GL Hager
Methods. 123: 76-88, 2017. [ Journal Article ]

Vaccine Induction of Lymph Node–Resident Simian Immunodeficiency Virus Env-Specific T Follicular Helper Cells in Rhesus Macaques

DA Vargas-Inchaustegui, A Demers, JM Shaw, G Kang, DA Ball, I Tuero, T Musich, V Mohanram, T Demberg, TS Karpova, Q Li, and M Robert-Guroff
J Immunol. 196: 1700-1710, 2016. [ Journal Article ]

Single molecule tracking of Ace1p in Saccharomyces cerevisiae defines a characteristic residence time for non-specific interactions of transcription factors with chromatin

DA Ball, GD Mehta, R Salomon-Kent, D Mazza, T Morisaki, F Mueller, JG McNally, and TS Karpova
Nucleic Acids Res. 44(21): e160, 2016. [ Journal Article ]

Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions

EE Swinstead, TB Miranda, V Paakinaho, S Baek, I Goldstein, M Hawkins, TS Karpova, DA Ball, D Mazza, LD Lavis, JB Grimm, T Morisaki, L Grøntved, DM Presman, and GL Hager
Cell. 165: 593-605, 2016. [ Journal Article ]