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Susan  Gottesman, Ph.D.

Susan Gottesman, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Gottesman has pioneered studies on post-transcriptional mechanisms of regulation in bacterial systems, with a focus on the role of energy-dependent proteolysis in regulation and the role of small non-coding RNAs in regulating translation and mRNA stability. One focus of her work has been on how these regulatory inputs affect the bacteria’s response to stress.

Areas of Expertise

1) microbial genetics, 2) bacterial regulatory RNAs, 3) ATP-dependent proteolysis

Publications

Selected Recent Publications

Phage Resistance in Multidrug-Resistant Klebsiella pneumoniae ST258 Evolves via Diverse Mutations That Culminate in Impaired Adsorption

Hesse S, Rajaure M, Wall E, Johnson J, Bliskovsky V, Gottesman S, Adhya S
mBio. 11(1): e02530-19, 2020. [ Journal Article ]

Structural basis for inhibition of a response regulator of σS stability by a ClpXP antiadaptor

Dorich V, Brugger C, Tripathi A, Hoskins JR, Tong S, Suhanovsky MM, Sastry A, Wickner S, Gottesman S, Deaconescu AM
Genes Dev. 33(11-12): 718-32, 2019. [ Journal Article ]

Regulation of acetate metabolism and coordination with the TCA cycle via a processed small RNA

De Mets F, Van Melderen L, Gottesman S
Proc Natl Acad Sci U S A. 116(3): 1043-52, 2019. [ Journal Article ]

The Complex Rcs Regulatory Cascade

Wall E, Majdalani N, Gottesman S
Annu Rev Microbiol. 72: 111-39, 2018. [ Journal Article ]

Hfq links translation repression to stress-induced mutagenesis in E. coli

Chen J, Gottesman S
Genes Dev. 31(13): 1382-95, 2017. [ Journal Article ]

Job Vacancies

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Team

Postdoctoral Fellow (Visiting)
Sophia Bouillet, Ph.D.
Postdoctoral Fellow (Visiting)
Xing Luo, Ph.D.
Postbaccalaureate Fellow (CRTA)
Abbigale Perkins, B.S.
Postdoctoral Fellow (Visiting)
Anushya Petchiappan, Ph.D.
Research Biologist
Song Tong