Stavroula Mili

Stavroula Mili, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Our research program focuses on the roles of localized RNAs in mammalian physiology. Our work spearheaded the study of RNAs targeted to protrusive regions of cells and established that protrusion localized mRNAs are functionally important during cell migration and cancer cell invasion. This mRNA localization mechanism is further linked to physiologically and clinically relevant processes since it occurs in vivo and is deregulated by pathogenic mutations. We use a variety of approaches including single-molecule RNA imaging in fixed and live cells, bioengineering methods as well as 3D and in vivo models. Our goal is to understand the molecular regulation, functional consequences and disease associations of localized RNAs.

Areas of Expertise

RNA Localization
Cell Migration
RNA Granules
Modified Microtubules
Local Translation


Selected Recent Publications

The kinesin KIF1C transports APC-dependent mRNAs to cell protrusions

Pichon X, Moissoglu K, Coleno E, Wang T, Imbert A, Robert M-C, Peter M, Chouaib R, Walter T, Mueller F, Zibara K, Bertrand E, Mili S
RNA. 27: 1528-1544, 2021. [ Journal Article ]

Collective cancer cell invasion requires RNA accumulation at the invasive front

Chrisafis G, Wang T, Moissoglu K, Gasparski AN,Ng Y, Weigert R, Lockett SJ, Mili S.
Proc Natl Acad Sci U S A . . 117(44): 27423-27434, 2020. [ Journal Article ]

RNA localization and co-translational interactions control RAB13 GTPase function and cell migration

Moissoglu K, Stueland M, Gasparski AN, Wang T, Jenkins LM, Hastings LM, Mili S.
EMBO Journal. 39(21): e104958, 2020. [ Journal Article ]

Translational regulation of protrusion-localized RNAs involves silencing and clustering after transport

Moissoglu K, Yasuda K, Wang T, Chrisafis G, Mili S.
eLife. 8: e44752, 2019. [ Journal Article ]

Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration

Wang T, Hamilla S, Cam M, Aranda-Espinoza H, Mili S.
Nat Commun. 8(1): 896, 2017. [ Journal Article ]

Job Vacancies

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Staff Scientist
Konstadinos Moissoglu, Ph.D.
Postdoctoral Fellow (CRTA)
Alexander N. Gasparski, Ph.D.
Postdoctoral Fellow (CRTA)
Devon E. Mason, Ph.D
Postbaccalaureate fellow
Vibha Sarathy
Postbaccalaureate fellow
Neal Jiwnani