Sergio Ruiz Macias, Ph.D.

Sergio Ruiz Macias, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Genome Integrity


I have always been amazed by how a single cell can originate a whole organism. Understanding cell plasticity, pluripotency and differentiation to get a better comprehension of embryonic development, cell transformation and cancer are my scientific interests.

Areas of Expertise

Embryonic Stem Cells
Somatic Cell Reprogramming
CRISPR-Based Screenings


Selected Recent Publications

CTCF is a barrier for 2C-like reprogramming

Olbrich T, Vega-Sendino M, Tillo D, Wu W, Zolnerowich N, Pavani R, Tran AD, Domingo CN, Franco M, Markiewicz-Potoczny M, Pegoraro G, FitzGerald PC, Kruhlak MJ, Lazzerini-Denchi E, Nora EP, Nussenzweig A, Ruiz S
Nat. Commun. 12(1):4856: 2021.
Full-Text Article
[ Journal Article ]

The ETS transcription factor ERF controls the exit from the naïve pluripotent state in a MAPK-dependent manner

Vega-Sendino M, Olbrich T, Tillo D, Tran AD, Domingo CN, Franco M, FitzGerald PC, Kruhlak MJ, Ruiz S
Sci. Adv. 7(40):eabg8306: 2021.
Full-Text Article
[ Journal Article ]

ERF deletion rescues RAS deficiency in mouse embryonic stem cells

Mayor-Ruiz C, Olbrich T, Drosten M, Lecona E, Vega-Sendino M, Ortega S, Dominguez O, Barbacid M, Ruiz S, and Fernández-Capetillo O.
Genes Dev. 32(7-8): 568-76, 2018.
Full-Text Article
[ Journal Article ]

A p53-dependent response limits the viability of mammalian haploid cells

Olbrich T, Mayor-Ruiz C, Vega-Sendino M, Gómez C, Ortega S, Ruiz S, and Fernández-Capetillo O.
Proc Natl Acad Sci U S A. 114: 9367-9372, 2017.
Full-Text Article
[ Journal Article ]

A genome-wide CRISPR screen identifies CDC25A as a determinant of sensitivity to ATR inhibitors

Ruiz S, Mayor-Ruiz C, Lafarga V, Murga M, Vega-Sendino M, Ortega S, and Fernández-Capetillo O.
Mol Cell. 62: 307-13, 2016.
Full-Text Article
[ Journal Article ]

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Bechara Saykali
Postdoctoral Fellow (Visiting)
Bechara Saykali, Ph.D.
Maria Vega Sendino
Maria Vega Sendino, Ph.D.
Sarah C. Hoelscher, Ph.D.
Bhavya Soni, B.S.


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