Sergio Ruiz Macias, Ph.D.

Sergio Ruiz Macias, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Genome Integrity


I have always been amazed by how a single cell can originate a whole organism. Understanding cell plasticity, pluripotency and differentiation to get a better comprehension of embryonic development, cell transformation and cancer are my scientific interests.

Areas of Expertise

Embryonic Stem Cells
Somatic Cell Reprogramming
CRISPR-Based Screenings


Selected Recent Publications

The homeobox transcription factor DUXBL controls exit from totipotency

Vega-Sendino M, Lüttmann FF, Olbrich T, Chen Y, Kuenne C, Stein P, Tillo D, Carey GI, Zhong J, Savy V, Radonova L, Lu T, Saykali B, Kim K, Domingo CN, Schüler L, Günther S, Bentsen M, Bosnakovski D, Schöler H, Kyba M, Maity TK, Jenkins LM, Looso M, Williams CJ, Kim J, Ruiz S
Nat Genet . DOI: 10.1038/s41588-024-01692-z: 2024. [ Journal Article ]

CTCF is a barrier for 2C-like reprogramming

Olbrich T, Vega-Sendino M, Tillo D, Wu W, Zolnerowich N, Pavani R, Tran AD, Domingo CN, Franco M, Markiewicz-Potoczny M, Pegoraro G, FitzGerald PC, Kruhlak MJ, Lazzerini-Denchi E, Nora EP, Nussenzweig A, Ruiz S
Nat. Commun. 12(1):4856: 2021.
Full-Text Article
[ Journal Article ]

The ETS transcription factor ERF controls the exit from the naïve pluripotent state in a MAPK-dependent manner

Vega-Sendino M, Olbrich T, Tillo D, Tran AD, Domingo CN, Franco M, FitzGerald PC, Kruhlak MJ, Ruiz S
Sci. Adv. 7(40):eabg8306: 2021.
Full-Text Article
[ Journal Article ]

ERF deletion rescues RAS deficiency in mouse embryonic stem cells

Mayor-Ruiz C, Olbrich T, Drosten M, Lecona E, Vega-Sendino M, Ortega S, Dominguez O, Barbacid M, Ruiz S, and Fernández-Capetillo O.
Genes Dev. 32(7-8): 568-76, 2018.
Full-Text Article
[ Journal Article ]

A p53-dependent response limits the viability of mammalian haploid cells

Olbrich T, Mayor-Ruiz C, Vega-Sendino M, Gómez C, Ortega S, Ruiz S, and Fernández-Capetillo O.
Proc Natl Acad Sci U S A. 114: 9367-9372, 2017.
Full-Text Article
[ Journal Article ]

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Bechara Saykali
Postdoctoral Fellow (Visiting)
Bechara Saykali, Ph.D.
Maria Vega Sendino
Maria Vega Sendino, Ph.D.
Sarah C. Hoelscher, Ph.D.
Bhavya Soni, B.S.


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