Sergio Ruiz Macias, Ph.D.

Sergio Ruiz Macias, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Genome Integrity


I have always been amazed by how a single cell can originate a whole organism. Understanding cell plasticity, pluripotency and differentiation to get a better comprehension of embryonic development, cell transformation and cancer are my scientific interests.

Areas of Expertise

1) embryonic stem cells, 2) pluripotency, 3) somatic cell reprogramming, 4) CRISPR-based screenings, 5) differentiation, 6) cell plasticity


Selected Recent Publications

CTCF is a barrier for 2C-like reprogramming

Olbrich T, Vega-Sendino M, Tillo D, Wu W, Zolnerowich N, Pavani R, Tran AD, Domingo CN, Franco M, Markiewicz-Potoczny M, Pegoraro G, FitzGerald PC, Kruhlak MJ, Lazzerini-Denchi E, Nora EP, Nussenzweig A, Ruiz S
Nat. Commun. 12(1):4856: 2021.
Full-Text Article
[ Journal Article ]

The ETS transcription factor ERF controls the exit from the naïve pluripotent state in a MAPK-dependent manner

Vega-Sendino M, Olbrich T, Tillo D, Tran AD, Domingo CN, Franco M, FitzGerald PC, Kruhlak MJ, Ruiz S
Sci. Adv. 7(40):eabg8306: 2021.
Full-Text Article
[ Journal Article ]

ERF deletion rescues RAS deficiency in mouse embryonic stem cells

Mayor-Ruiz C, Olbrich T, Drosten M, Lecona E, Vega-Sendino M, Ortega S, Dominguez O, Barbacid M, Ruiz S, and Fernández-Capetillo O.
Genes Dev. 32(7-8): 568-76, 2018.
Full-Text Article
[ Journal Article ]

A p53-dependent response limits the viability of mammalian haploid cells

Olbrich T, Mayor-Ruiz C, Vega-Sendino M, Gómez C, Ortega S, Ruiz S, and Fernández-Capetillo O.
Proc Natl Acad Sci U S A. 114: 9367-9372, 2017.
Full-Text Article
[ Journal Article ]

A genome-wide CRISPR screen identifies CDC25A as a determinant of sensitivity to ATR inhibitors

Ruiz S, Mayor-Ruiz C, Lafarga V, Murga M, Vega-Sendino M, Ortega S, and Fernández-Capetillo O.
Mol Cell. 62: 307-13, 2016.
Full-Text Article
[ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Post-doctoral Fellow - Embryonic stem cells, Chromatin architecture Ph.D. or equivalent Sergio Ruiz Macias


Postdoctoral Fellow (Visiting)
Bechara Saykali, Ph.D.
Maria Vega Sendino, B.S.
Postbaccalaureate Fellow (CRTA)
Grace Carey