Robert  Yarchoan, M.D.

Robert Yarchoan, M.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Yarchoan has played a major role in developing the first successful drugs to treat HIV infection. More recently, his research is focused on the study of and development of treatment for HIV-associated malignancies, with a focus on those caused by Kaposi sarcoma-associated herpesvirus (KSHV). As Chief, Dr. Yarchoan oversees the Branch’s clinical/translational research program, which encompasses the development of novel therapies for HIV infection, the study of the viral causes of HIV-associated malignancies, and the development of novel therapies for HIV-associated malignancies.

Areas of Expertise

Kaposi's Sarcoma-Associated Herpesvirus (KSHV) /Human Herpesvirus-8 (HHV-8)
Kaposi Sarcoma
Viral Oncogenesis
Hypoxia Inducible Factors

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them. 


Selected Recent Publications

Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300

Davis DA, Bulut H, Shrestha P, Yaparla A, Jaeger HK, Hattori SI, Wingfield PT, Mieyal JJ, Mitsuya H, Yarchoan R.
mBio. 12 (4): e0209421, 2021.
Full-Text Article
[ Journal Article ]

Pomalidomide restores immune recognition of primary effusion lymphoma through upregulation of ICAM-1 and B7-2

Shrestha P, Davis DA, Jaeger HK, Stream A, Aisabor AI, Yarchoan R.
PLoS Pathog. 17 (1): e1009091, 2021.
Full-Text Article
[ Journal Article ]

Characteristics and outcomes of KSHV-associated multicentric Castleman disease with or without other KSHV diseases

Ramaswami R, Lurain K, Polizzotto MN, Ekwede I, Waldon K, Steinberg SM, Mangusan R, Widell A, Rupert A, George J, Gonçalves PH, Marshall VA, Whitby D, Wang HW, Pittaluga S, Jaffe ES, Little RF, Uldrick TS, Yarchoan R.
Blood Adv. 5(6): 1660-1670, 2021.
Full-Text Article
[ Journal Article ]

Induction of Kaposi Sarcoma Associated Herpesvirus-encoded Thymidine Kinase (ORF21) by X-Box Binding Protein-1

Wang V, Davis DA, Deleage C, Brands C, Choi HS, Haque M, Yarchoan R.
J Virol. 94(5): e01555-19, 2020.
Full-Text Article
[ Journal Article ]

Treatment of HIV-associated primary CNS lymphoma with antiretroviral therapy, rituximab, and high-dose methotrexate

Lurain K, Uldrick TS, Ramaswami R, Polizzotto M, Goncalves P, Widell A, Steinberg SM, Jaffe ES, Pittaluga S, Wang HW, Yuan C, Tamula MA, Martin S, Wolters PL, George J, Little RF, Yarchoan R
Blood. 136(19): 2229-2232, 2020. [ Journal Article ]

Job Vacancies

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Postbaccalaureate Fellow (CRTA)
Yana Astter, B.S.
Research Nurse
Irene Ekwede, R.N.
Nurse Practitioner (Contr.)
Ralph Mangusan, CRNP
Data Manager (Contr.)
Sejal Mendpara
Postdoctoral Fellow (Visiting)
Ashwin K. Nair, Ph.D.
Research Fellow
Prabha Shrestha, Ph.D.
Research Biologist
Victoria Wang, M.D.
Research Nurse
Anaida Widell, R.N.
Postdoctoral Fellow (Visiting)
Yi-Quan Wu, Ph.D.