Robert  Yarchoan, M.D.

Robert Yarchoan, M.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Yarchoan has played a major role in developing the first successful drugs to treat HIV infection. More recently, his research is focused on the study of and development of treatment for HIV-associated malignancies, with a focus on those caused by Kaposi sarcoma-associated herpesvirus (KSHV). As Chief, Dr. Yarchoan oversees the Branch’s clinical/translational research program, which encompasses the development of novel therapies for HIV infection, the study of the viral causes of HIV-associated malignancies, and the development of novel therapies for HIV-associated malignancies.

Areas of Expertise

Kaposi's Sarcoma-Associated Herpesvirus (KSHV) /Human Herpesvirus-8 (HHV-8)
Kaposi Sarcoma
Viral Oncogenesis
Hypoxia Inducible Factors

Information for Patients

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Selected Recent Publications

Mechanism and therapeutic implications of pomalidomide-induced immune surface marker upregulation in EBV-positive lymphomas.

Jaeger HK, Davis DA, Nair A, Shrestha P, Stream A, Yaparla A, Yarchoan R.
Sci Rep. 13(1): 11596, 2023.
Full-Text Article
[ Journal Article ]

Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300

Davis DA, Bulut H, Shrestha P, Yaparla A, Jaeger HK, Hattori SI, Wingfield PT, Mieyal JJ, Mitsuya H, Yarchoan R.
mBio. 12 (4): e0209421, 2021.
Full-Text Article
[ Journal Article ]

Pomalidomide restores immune recognition of primary effusion lymphoma through upregulation of ICAM-1 and B7-2

Shrestha P, Davis DA, Jaeger HK, Stream A, Aisabor AI, Yarchoan R.
PLoS Pathog. 17 (1): e1009091, 2021.
Full-Text Article
[ Journal Article ]

Characteristics and outcomes of KSHV-associated multicentric Castleman disease with or without other KSHV diseases

Ramaswami R, Lurain K, Polizzotto MN, Ekwede I, Waldon K, Steinberg SM, Mangusan R, Widell A, Rupert A, George J, Gonçalves PH, Marshall VA, Whitby D, Wang HW, Pittaluga S, Jaffe ES, Little RF, Uldrick TS, Yarchoan R.
Blood Adv. 5(6): 1660-1670, 2021.
Full-Text Article
[ Journal Article ]

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Research Nurse
Irene Ekwede, R.N.
Nurse Practitioner (Contr.)
Ralph Mangusan, CRNP
Data Manager (Contr.)
Sejal Mendpara
Postdoctoral Fellow (Visiting)
Ashwin K. Nair, Ph.D.
Research Biologist
Victoria Wang, M.D.
Research Nurse
Anaida Widell, R.N.
Postbaccalaureate Fellow (CRTA)
Emma Treco, B.S.


Dr. Robert Yarchoan, Chief of HAMB, delivered an opening plenary talk on HIV/AIDS-associated malignancies at the 2023 AACR meeting. He discussed the changes in HIV malignancy as the AIDS epidemic evolved, cancer immunotherapy in people with HIV, and advances in Kaposi sarcoma and related diseases