Paul S. Meltzer, M.D., Ph.D.

Paul S. Meltzer, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Meltzer is a leader in the application of genome science to cancer research. His recent studies investigate the genetic and epigenetic basis of cancers in adult and pediatric patients, particularly those with bone and soft tissue sarcomas. Dr. Meltzer's long-term goal is to improve diagnosis and therapy through better understanding of the mechanisms driving tumor growth. As Branch Chief, Dr. Meltzer oversees a program focused on the mechanisms and consequences of genome instability, non-coding RNA biology, and translational genomics. Developing applications of genome technologies for the oncology clinic is an important priority within the Branch.

Areas of Expertise


Selected Recent Publications

Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis

Marie KL, Sassano A, Yang HH, Michalowski AM, Michael HT, Guo T, Tsai YC, Weissman AM, Lee MP, Jenkins LM, Zaidi MR, Pérez-Guijarro E, Day CP, Ylaya K, Hewitt SM, Patel NL, Arnheiter H, Davis S, Meltzer PS, Merlino G, Mishra PJ.
Nat Commun. 11(1): 333, 2020. [ Journal Article ]

RNA Sequencing of the NCI-60: Integration into CellMiner and CellMiner CDB

Reinhold WC, Varma S, Sunshine M, Elloumi F, Ofori-Atta K, Lee S, Trepel JB, Meltzer PS, Doroshow JH, Pommier Y.
Cancer Res. 79(13): 3514-24, 2019. [ Journal Article ]

Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background

Yin M, Chung YJ, Lindsley RC, Walker RL, Zhu YJ, Ebert BL, Meltzer PS, Aplan PD.
Blood. 133(24): 2610-14, 2019. [ Journal Article ]

Activity of durvalumab plus olaparib in metastatic castration-resistant prostate cancer in men with and without DNA damage repair mutations

Karzai F, VanderWeele D, Madan RA, Owens H, Cordes LM, Hankin A, Couvillon A, Nichols E, Bilusic M, Beshiri ML, Kelly K, Krishnasamy V, Lee S, Lee MJ, Yuno A, Trepel JB, Merino MJ, Dittamore R, Marté J, Donahue RN, Schlom J, Killian KJ, Meltzer PS, Steinberg SM, Gulley JL, Lee JM, Dahut WL.
J Immunother Cancer. 6(1): 141, 2018. [ Journal Article ]

Outcomes of Children and Adolescents with Advanced Hereditary Medullary Thyroid Carcinoma Treated with Vandetanib

Kraft IL, Akshintala S, Zhu Y, Lei H, Derse-Anthony C, Dombi E, Steinberg SM, Lodish M, Waguespack SG, Kapustina O, Fox E, Balis FM, Merino MJ, Meltzer PS, Glod JW, Shern JF, Widemann BC.
Clin Cancer Res. 24(4): 753-65, 2018. [ Journal Article ]

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Research Fellow
Sarah Clatterbuck-Soper, Ph.D.
John E. Lueders
Research Fellow
Sanjit Mukherjee, Ph.D.
Marbin Pineda
Robert L. Walker, B.S.
Yonghong Wang, Ph.D.
Fan Yang, Ph.D.
Yuelin (Jack) Zhu, M.D., M.S.
Program Specialist
Jenna Whipp, B.S
Information Technology Specialist
Buddy Chen, B.S.
Wei-Dong Chen, Ph.D.
Sanam Yaghobi
Predoctoral Visiting Fellow
Sanam Yaghoubi


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