Breadcrumb

Paul S. Meltzer, M.D., Ph.D.

Paul S. Meltzer, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Meltzer is a leader in the application of genome science to cancer research. His recent studies investigate the genetic and epigenetic basis of cancers in adult and pediatric patients, particularly those with bone and soft tissue sarcomas. Dr. Meltzer's long-term goal is to improve diagnosis and therapy through better understanding of the mechanisms driving tumor growth. As Branch Chief, Dr. Meltzer oversees a program focused on the mechanisms and consequences of genome instability, non-coding RNA biology, and translational genomics. Developing applications of genome technologies for the oncology clinic is an important priority within the Branch.

Areas of Expertise

1) cancer genomics, 2) cancer genetics, 3) sarcoma, 4) pediatric oncology,
5) genome technology, 6) epigenetics

Publications

Selected Recent Publications

Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis

Marie KL, Sassano A, Yang HH, Michalowski AM, Michael HT, Guo T, Tsai YC, Weissman AM, Lee MP, Jenkins LM, Zaidi MR, Pérez-Guijarro E, Day CP, Ylaya K, Hewitt SM, Patel NL, Arnheiter H, Davis S, Meltzer PS, Merlino G, Mishra PJ.
Nat Commun. 11(1): 333, 2020. [ Journal Article ]

RNA Sequencing of the NCI-60: Integration into CellMiner and CellMiner CDB

Reinhold WC, Varma S, Sunshine M, Elloumi F, Ofori-Atta K, Lee S, Trepel JB, Meltzer PS, Doroshow JH, Pommier Y.
Cancer Res. 79(13): 3514-24, 2019. [ Journal Article ]

Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background

Yin M, Chung YJ, Lindsley RC, Walker RL, Zhu YJ, Ebert BL, Meltzer PS, Aplan PD.
Blood. 133(24): 2610-14, 2019. [ Journal Article ]

Activity of durvalumab plus olaparib in metastatic castration-resistant prostate cancer in men with and without DNA damage repair mutations

Karzai F, VanderWeele D, Madan RA, Owens H, Cordes LM, Hankin A, Couvillon A, Nichols E, Bilusic M, Beshiri ML, Kelly K, Krishnasamy V, Lee S, Lee MJ, Yuno A, Trepel JB, Merino MJ, Dittamore R, Marté J, Donahue RN, Schlom J, Killian KJ, Meltzer PS, Steinberg SM, Gulley JL, Lee JM, Dahut WL.
J Immunother Cancer. 6(1): 141, 2018. [ Journal Article ]

Outcomes of Children and Adolescents with Advanced Hereditary Medullary Thyroid Carcinoma Treated with Vandetanib

Kraft IL, Akshintala S, Zhu Y, Lei H, Derse-Anthony C, Dombi E, Steinberg SM, Lodish M, Waguespack SG, Kapustina O, Fox E, Balis FM, Merino MJ, Meltzer PS, Glod JW, Shern JF, Widemann BC.
Clin Cancer Res. 24(4): 753-65, 2018. [ Journal Article ]

Job Vacancies

There are no open positions at this time. Check back again later, or take a look at CCR's Careers page.

Team

Research Fellow
Sarah Clatterbuck-Soper, Ph.D.
Post-Masters (CRTA)
James Dalgleish
Research Biologist
John E. Lueders
Research Fellow
Sanjit Mukherjee, Ph.D.
Research Biologist
David Petersen, B.A.
Research Biologist
Marbin Pineda
Research Biologist
Robert L. Walker, B.S.
Research Biologist
Jennifer Walling, M.S.
Research Biologist
Yonghong Wang, Ph.D.
Research Biologist
Fan Yang, Ph.D.
Research Biologist
Yuelin (Jack) Zhu, M.D., M.S.
Program Support Specialist
Kristen Martin
Program Specialist
Jenna Whipp, B.S