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Kerstin  Heselmeyer-Haddad, Ph.D.

Kerstin Heselmeyer-Haddad, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Genetics Branch

RESEARCH SUMMARY

Dr. Heselmeyer-Haddad discovered that the majority of cervical carcinomas carry extra copies of the long arm of chromosome 3. She developed a diagnostic FISH test for the telomerase RNA component (TERC) on 3q which can differentiate low-grade from high-grade cervical disease with high sensitivity and specificity. The 3q test is now offered by several diagnostic labs. She recently developed a multiplex FISH assay that allows the simultaneous analysis of copy number changes of up to 10 tumor-specific genes on a single cell basis.

Areas of Expertise

fluorescence in situ hybridization (FISH), cancer genetics (cervix, breast, prostate, colon-rectum), 3q test, multiplex FISH single cell assay

Publications

Selected Publications

Detection of genomic amplification of the human telomerase gene TERC, a potential marker for triage of women with HPV-positive, abnormal Pap smears

Andersson S, Sowjanya P, Wangsa D, Hjerpe A, Johansson B, Auer G, Gravitt PE, Larsson C, Wallin KL, Ried T, Heselmeyer-Haddad K.
Am. J. Pathol.. 175: 1831-47, 2009. [ Journal Article ]

CD4+ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection

Kugler DG, Mittelstadt PR, Ashwell JD, Sher A, Jankovic D.
J. Exp. Med.. 210: 1919-27, 2013. [ Journal Article ]

Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation

Jirmanova L, Giardino Torchia ML, Sarma ND, Mittelstadt PR, Ashwell JD.
Blood. 118: 3280-9, 2011. [ Journal Article ]

Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix

Heselmeyer K, Schröck E, du Manoir S, Blegen H, Shah K, Steinbeck R, Auer G, Ried T.
Proc. Natl. Acad. Sci. U.S.A.. 93: 479-84, 1996. [ Journal Article ]

Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer

Heselmeyer-Haddad K, Sommerfeld K, White NM, Chaudhri N, Morrison LE, Palanisamy N, Wang ZY, Auer G, Steinberg W, Ried T.
Am. J. Pathol.. 166: 1229-38, 2005. [ Journal Article ]