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Patricia Steeg

Patricia S. Steeg, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Steeg investigates mechanisms of breast cancer metastasis. She discovered the first metastasis suppressor gene, nm23 (NME). Her recent work investigates brain metastasis of breast cancer. The Steeg lab has identified pathways that mediate brain metastasis, potential preventives, and studied the composition and role of the blood-tumor barrier. An open Phase I/II clinical trial of low dose, metronomic temozolomide for secondary prevention of brain metastases of breast cancer is based on the lab's preclinical data.

Areas of Expertise

1) breast cancer 2) metastasis 3) brain metastasis 4) metastasis suppressor genes 5) blood-tumor barrier

Publications

Selected Recent Publications

The Blood-Tumor Barrier in cancer biology and therapy

Steeg, P.S.
Nat. Rev. Clin. Oncol.. 18/11: 696-714, 2021.
Full-Text Article
[ Journal Article ]

Aging and microglial depletion attenuate breast cancer brain metastasis

Wu, A.M.L., Gossa, S., Samala, R., Chung, M., Gril, B., Yang, H., Thorsheim, H., Tran, A.D., Wei, D., Taner, E., Isnogle, K., Yang, Y., Dolan, E., Robinson, C., Difilippantonio, S., Lee, M.P., Khan, I., Smith, Q., McGavern, D., Wakefield, L.M., Steeg, P.S.
Clin. Cancer Res.. 27/15: 4422-4434, 2021.
Full-Text Article
[ Journal Article ]

Profound prevention of experimental brain metastases of breast cancer by temozolomide in a MGMT-dependent manner

Palmieri, D., Duchnowska, R., Woditschka, S., Hua, E., Qian, Y., Biernat, W., Sosinska-Melcarek, K., Gril, B., Stark, A.M., Hewitt, S.M., Liewehr, D.J., Steinberg, S.M., Jassem, J., Steeg, P.S.
Clin. Cancer Res.. 20/10: 2727- 2739, 2014.
Full-Text Article
[ Journal Article ]

Reactive astrocyte S1P3 signaling modulates the blood-tumor barrier in brain metastases

Gril, B., Parankape, A.N., Woditschka, S., Hua, E., Dolan, E., Hanson, J., Wu, X., Kloc, W., Izycka-Swieszewska, E., Duchnowska, R., Peksa, R., Biernat, W., Jassem, J., Nayyar, N., Brastianos, P.K., Hall, O., Peer, C.J., Figg, W.D., Pauly, G.T., Robinson, C., Difilippanonio, S., Bialecki, E., Metellus, P., Schneider, J.P., Steeg, P.S.
Nature Comm.. 9/1: 2705, 2018.
Full-Text Article
[ Journal Article ]

Heterogeneous Permeability of Experimental Brain Metastases of Breast Cancer Associated with Blood-Brain Barrier Remodeling

Lockman, P.R., Mittapalli, R.K., Taskar, K., Rudraraju, V., Gril, B., Bohn, K.A., Adkins, C., Thomas, F.C., Thorsheim, H.R., Gaasch, J.A., Huang, S., Palmieri, D., Steeg, P.S., Smith, Q.R.
Clin Cancer Res. 16/23: 5664-5678, 2010.
Full-Text Article
[ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Post-doctoral Fellow - CNS, metastasis, breast cancer Ph.D. or equivalent Josselyn White josselyn.white@nih.gov

Team

Biologist
Debbie Wei, B.S.
Nurse Practitioner
Britanny Brooke Solarz, R.N., B.S.N.
Research Nurse
Ann McCoy, R.N.
PostBaccalaureate
Yewande Adisa, B.S.