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Patricia S. Steeg, Ph.D.

Patricia S. Steeg, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Steeg investigates mechanisms of breast cancer metastasis. She discovered the first metastasis suppressor gene, nm23 (NME). Her recent work investigates brain metastasis of breast cancer. The Steeg lab has identified pathways that mediate brain metastasis, potential preventives, and studied the composition and role of the blood-tumor barrier. An open Phase I/II clinical trial of low dose, metronomic temozolomide for secondary prevention of brain metastases of breast cancer is based on the lab's preclinical data.

Areas of Expertise

1) breast cancer 2) metastasis 3) brain metastasis 4) metastasis suppressor genes 5) blood-tumor barrier 6) blood-brain barrier

Publications

Selected Recent Publications

A HER2 Antibody Drug Conjugate Controls Growth of Breast Cancer Brain Metastases in Hematogenous Xenograft Models, with Heterogeneous Blood-Tumor Barrier Penetration Unlinked to a Passive Marker

Gril B, Wei D, Zimmer AS, Robinson C, Khan I, Difilippantonio S, Overstreet MG, Steeg PS.
Neuro Oncol. [Epub ahead of print], 2020. [ Journal Article ]

Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases

Gril B, Paranjape AN, Woditschka S, Hua E, Dolan EL, Hanson J, Wu X, Kloc W, Izycka-Swieszewska E, Duchnowska R, Pęksa R, Biernat W, Jassem J, Nayyar N, Brastianos PK, Hall OM, Peer CJ, Figg WD, Pauly GT, Robinson C, Difilippantonio S, Bialecki E, Metellus P, Schneider JP, Steeg PS.
Nat Commun. 9(1): 2705, 2018. [ Journal Article ]

Limited fibrosis accompanies triple-negative breast cancer metastasis in multiple model systems and is not a preventive target

Brooks D, Zimmer A, Wakefield L, Lyle LT, Difilippantonio S, Tucci FC, Illiano S, Annunziata CM, Steeg PS.
Oncotarget. 9(34): 23462-81, 2018. [ Journal Article ]

Therapeutics for Brain Metastases, v3

Steeg PS, Zimmer A, Gril B.
Clin Cancer Res. 22(24): 5953-55, 2016. [ Journal Article ]

Job Vacancies

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Team

Staff Scientist
Imran Khan, Ph.D.
Research Nurse
Ann McCoy, R.N.
Postdoctoral Fellow (CRTA)
Vanesa Silvestri, Ph.D.
Nurse Practitioner
Britanny Brooke Solarz, R.N., B.S.N.
Biologist
Debbie Wei, B.S.
PostBaccalaureate
Yewande Adisa, B.S.
PostDoctoral
Samiur Rahman, Ph.D.
Staff Scientist
Wei Zhang, Ph.D.