Breadcrumb

Michael M. Gottesman, M.D.

Michael M. Gottesman, M.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Gottesman and colleagues pioneered the characterization of molecular mechanisms that result in failure to cure cancer with chemotherapy. They now focus on mechanisms that reduce accumulation of cytotoxic drugs in cancer cells, including reduced drug uptake and increased energy-dependent drug efflux by ABC transporters such as P-glycoprotein (ABCB1), ABCC1 (MRP), and ABCG2 (BCRP). They seek to define molecular tools to detect resistance mechanisms in cancers and devise ways to circumvent or exploit this resistance for treatment of multidrug-resistant cancers. An additional goal is to define the physiological role of these multidrug transporters in normal human tissues, e.g. at the blood-brain barrier.

Areas of Expertise

1) multidrug resistance, 2) ABC transporters, 3) thiosemicarbazides, 4) blood-brain barrier, 5) chemotherapy

Publications

Selected Key Publications

CHO mutants resistant to colchicine, colcemid or griseofulvin have an altered beta-tubulin

Cabral F, Sobel ME, Gottesman MM.
Cell. 20: 29-36, 1980. [ Journal Article ]

Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification

Shen DW, Fojo A, Chin JE, Roninson IB, Richert N, Pastan I, Gottesman MM.
Science. 232: 643-5, 1986. [ Journal Article ]

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

Chen CJ, Chin JE, Ueda K, Clark DP, Pastan I, Gottesman MM, Roninson IB.
Cell. 47: 381-9, 1986. [ Journal Article ]

Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver

Thorgeirsson SS, Huber BE, Sorrell S, Fojo A, Pastan I, Gottesman MM.
Science. 236: 1120-2, 1987. [ Journal Article ]

A "silent" polymorphism in the MDR1 gene changes substrate specificity

Kimchi-Sarfaty C, Oh JM, Kim I, Sauna ZE, Calcagno AM, Ambudkar SV, Gottesman MM.
Science. 315: 525-8, 2007. [ Journal Article ]

Job Vacancies

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Team

Research Chemist
Robert Robey, Ph.D.
Postdoctoral Fellow (CRTA)
Crystal Chari Cole Lipsey, Ph.D.
Postdoctoral Fellow (CRTA)
Allison Mitchell, Ph.D.
Postdoctoral Fellow (Visiting)
Joanna Thomas, Ph.D.
Predoctoral IRTA (Graduate Student)
Colin Inglut
Predoctoral Fellow
Heidi Wade
Clinical Fellow
Annika Deitermann
Visiting Fellow
Priya Mondal, Ph.D.
Postbaccalaureate Fellow
William Frye
Postbaccalaureate Fellow
José Gonzalez Dalmasy