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Michael M. Gottesman, M.D.

Michael M. Gottesman, M.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Gottesman and colleagues pioneered the characterization of molecular mechanism that result in failure to cure cancer with chemotherapy.  One focus is on mechanisms that reduce accumulation of cytotoxic drugs in cancer cells, including reduced drug uptake and increased energy-dependent drug efflux by ABC transporters such as P-glycoprotein (ABCB1) and ABCG2 (BCRP).  These ABC transporters also make up chemical barriers to successful chemotherapy of brain tumors as part of the Blood-Brain Barrier. Using CRISPR-cas based genomic approaches, they are cataloguing mechanisms that more broadly confer drug resistance in colon, ovarian, and cervical cancers. The goal of this work is to devise ways to circumvent or exploit the physiologically relevant anti-cancer drug resistance mechanisms.

Areas of Expertise

Multidrug Resistance 
ABC Transporters 
Histone Deacetylase Inhibitors
Blood-Brain Barrier 
Chemotherapy

Publications

Selected Key Publications

CHO mutants resistant to colchicine, colcemid or griseofulvin have an altered beta-tubulin

Cabral F, Sobel ME, Gottesman MM.
Cell. 20: 29-36, 1980. [ Journal Article ]

Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification

Shen DW, Fojo A, Chin JE, Roninson IB, Richert N, Pastan I, Gottesman MM.
Science. 232: 643-5, 1986. [ Journal Article ]

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

Chen CJ, Chin JE, Ueda K, Clark DP, Pastan I, Gottesman MM, Roninson IB.
Cell. 47: 381-9, 1986. [ Journal Article ]

Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver

Thorgeirsson SS, Huber BE, Sorrell S, Fojo A, Pastan I, Gottesman MM.
Science. 236: 1120-2, 1987. [ Journal Article ]

A "silent" polymorphism in the MDR1 gene changes substrate specificity

Kimchi-Sarfaty C, Oh JM, Kim I, Sauna ZE, Calcagno AM, Ambudkar SV, Gottesman MM.
Science. 315: 525-8, 2007. [ Journal Article ]

Job Vacancies

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Team

Research Chemist
Robert Robey, Ph.D.
Postdoctoral Fellow (CRTA)
Crystal Chari Cole Lipsey, Ph.D.
Postdoctoral Fellow (CRTA)
Allison Mitchell, Ph.D.
Postdoctoral Fellow (Visiting)
Joanna Thomas, Ph.D.
Postdoctoral Fellow (CRTA)
Nisha Pawar, Ph.D.
Visiting Fellow
Priya Mondal, Ph.D.
Post-doctoral Fellow (Visiting)
Ednah Ooko, Ph.D.
Postbaccalaureate Fellow
William Frye
Postbaccalaureate Fellow
José Gonzalez Dalmasy
Predoctoral Fellow (Graduate Student)
John Quinlan
Post-Baccalaureate Fellow
Sashank Sabbineni

News

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