Job Description
A postdoctoral position is available in the laboratory of Dr. Michael M. Gottesman in the Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute. The M. Gottesman lab has been at the forefront of discovery in the field of multidrug efflux transporter biology since its inception. Transporters that confer multidrug resistance in cancer also prevent drugs from crossing the blood-brain barrier (BBB), creating a formidable challenge for the treatment of brain cancers (PMID: 29643473).
In recent years, the M. Gottesman lab has advanced zebrafish as a model organism for studying transporters and the BBB (PMID: 34921178; PMID: 38491505; PMID: 38141369). We have developed a transgenic larval bioluminescent assay that measures BBB integrity in response to perturbations designed to enhance drug delivery to the brain. This assay is complemented by in vivo confocal imaging, toxicity assays, CRISPR-knock-out mutants, and cell-based orthogonal methods. Xenograft models will be utilized to assess the effectiveness of approaches that disrupt the BBB and increase drug delivery to the brain in treating brain cancer.
As a postdoctoral fellow, you will join a vibrant, collaborative research community with cutting-edge facilities, abundant training opportunities, experienced mentorship, and an outstanding track record in career development. The NIH has the largest zebrafish facility in the world, multiple supporting core facilities, and a diverse research network. The successful candidate will play a crucial role in leading the lab’s zebrafish research, fostering intra and extramural collaborations, and actively engaging in mentoring.
Qualifications and Job Details
Required and Preferred Skills
Strong knowledge and experience working with zebrafish is essential. The ideal candidate is expected to possess adept skills in molecular biology, excellent record-keeping, strong written and verbal communication skills, a track record of mentoring, and a collaborative mindset.
Experience with colony management and microinjections is desired.
About the NCI Center for Cancer Research
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
Bethesda
Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.
Please use the subject line "Zebrafish postdoc application" in your e-mail.