Maxwell P. Lee, Ph.D.

Maxwell P. Lee, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Cancer Biology and Genetics


Integrated genomic and epigenomic studies of breast cancer: an allelic-specific perspective My research involves applying my expertise in genomics and epigenomics to dissecting out the components of breast cancer. I have been focusing on elucidating allele-specific gene expression and allele-specific epigenetic modifications. We developed a specific adaptation of SNP array-based high throughput technology. We showed that differential expression from the two alleles of a given gene is common in normal tissue. We followed this by demonstrating that the genetic background influences the epigenetic state of chromatin.

Areas of Expertise

Breast Cancer


Selected Recent Publications

Cooperative Targets of Combined mTOR/HDAC Inhibition Promote MYC Degradation

Simmons JK, Michalowski AM, Gamache BJ, DuBois W, Patel J, Zhang K, Gary J, Zhang S, Gaikwad S, Connors D, Watson N, Leon E, Chen JQ, Kuehl WM, Lee MP, Zingone A, Landgren O, Ordentlich P, Huang J, Mock BA.
Mol Cancer Ther. 16(9): 2008-2021, 2017. [ Journal Article ]

Immunocompetent mouse allograft models for development of therapies to target breast cancer metastasis

Yang Y, Yang HH, Hu Y, Watson PH, Liu H, Geiger TR, Anver MR, Haines DC, Martin P, Green JE, Lee MP, Hunter KW, Wakefield LM.
Oncotarget. 8(19): 30621-30643, 2017. [ Journal Article ]

The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis

Aprelikova O, Chen K, El Touny LH, Brignatz-Guittard C, Han J, Qiu T, Yang HH, Lee MP, Zhu M, Green JE.
Clin Epigenetics. 8: 38, 2016. [ Journal Article ]

An Integrated Genome-Wide Systems Genetics Screen for Breast Cancer Metastasis Susceptibility Genes

Bai L, Yang HH, Hu Y, Shukla A, Ha NH, Doran A, Faraji F, Goldberger N, Lee MP, Keane T, Hunter KW.
PLoS Genet. 12(4): e1005989, 2016. [ Journal Article ]

Genomic Landscape of Somatic Alterations in Esophageal Squamous Cell Carcinoma and Gastric Cancer

Hu N, Kadota M, Liu H, Abnet CC, Su H, Wu H, Freedman ND, Yang HH, Wang C, Yan C, Wang L, Gere S, Hutchinson A, Song G, Wang Y, Ding T, Qiao YL, Koshiol J, Dawsey SM, Giffen C, Goldstein AM, Taylor PR, Lee MP.
Cancer Res. 76(7): 1714-23, 2016. [ Journal Article ]


Bioinformatics Scientist (Contr.)
Huaitian Liu, Ph.D.

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