Howard H. Yang, Ph.D.

Howard H. Yang, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Yang integrates genomics and epigenomics data using statistics and machine learning method to discover genes and epigenetic markers important for understanding human cancers and to study their functions in the normal and cancer cells. He conducts genome-wide analysis of genotype, copy number, expression and methylation data in the esophageal cancer and gastric cancer study to find SNPs, genes and methylation markers related to the cancer risk and patient survival. Similarly, he also analyzes expression and methylation profiles in breast cancer, colon cancer and liver cancer studies to detect markers related to the patient survival, metastasis-free survival and relapse-free survival.

Areas of Expertise

Genetics And Genomics
Computational Biology
Systems Biology


Selected Recent Publications

Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy

Eva Pérez-Guijarro, Howard H. Yang, Romina E. Araya, Rajaa El Meskini, Helen T. Michael, Suman Kumar Vodnala, Kerrie L. Marie, Cari Smith, Sung Chin, Khiem C. Lam, Andres Thorkelsson, Anthony J. Iacovelli, Alan Kulaga, Anyen Fon, Aleksandra M. Michalowski, Willy Hugo, Roger S. Lo, Nicholas P. Restifo, Shyam K. Sharan, Terry Van Dyke, Romina S. Goldszmid, Zoe Weaver Ohler, Maxwell P. Lee, Chi-Ping Day, Glenn Merlino
Nature Medicine. 26: 781-791, 2020.
Full-Text Article
[ Journal Article ]

Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis

Kerrie L. Marie, Antonella Sassano, Howard H. Yang, Aleksandra M. Michalowski, Helen T. Michael, Theresa Guo, Yien Che Tsai, Allan M. Weissman, Maxwell P. Lee, Lisa M. Jenkins, M. Raza Zaidi, Eva Pérez-Guijarro, Chi-Ping Day, Kris Ylaya, Stephen M. Hewitt, Nimit L. Patel, Heinz Arnheiter, Sean Davis, Paul S. Meltzer, Glenn Merlino, Pravin J. Mishra
Nature Communications. 11: 333, 2020.
Full-Text Article
[ Journal Article ]

Integrated analysis of genome-wide miRNAs and targeted gene expression in esophageal squamous cell carcinoma (ESCC) and relation to prognosis

H. H. Yang, H. Su, N. Hu, C. Wang, L. Wang, C. Giffen, A. M. Goldstein, M. P. Lee and P. R. Taylor
BMC Cancer. 20: 388, 2020.
Full-Text Article
[ Journal Article ]

CBFB cooperates with p53 to maintain TAp73 expression and suppress breast cancer

Navdeep Malik, Hualong Yan, Howard H Yang, Gamze Ayaz, Wendy DuBois, Yu-Chou Tseng, Young-Im Kim, Shunlin Jiang, Chengyu Liu, Maxwell Lee, Jing Huang
PLOS Genetics. 17: e1009553, 2021.
Full-Text Article
[ Journal Article ]

Modified eQTL and Somatic DNA Segment Alterations in Esophageal Squamous Cell Carcinoma for Genes Related to Immunity, DNA Repair, and Inflammation

H. H. Yang, H. Liu, N. Hu, H. Su, C. Wang, C. Giffen, A. M. Goldstein, P. R. Taylor, M. P. Lee
Cancers. 14: 1629, 2022.
Full-Text Article
[ Journal Article ]