Headshot of Mark Gilbert

Mark R. Gilbert, M.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Gilbert has focused much of his effort to develop a unified team within the NCI Center for Cancer Research's Neuro-Oncology Branch (NOB), in order to perform cutting-edge research that advances knowledge in the brain tumor field. In turn, this would enable using these findings to develop robust clinical trials to improve patient outcomes through utilizing innovative combination treatments and precision medicine approaches. 

His primary research concentrations are in the areas of immunotherapy and precision therapy. For immunotherapy, he and his team are working to develop combination therapies that can increase immune cell recruitment to the tumor site and improve patient selection in clinical trials to maximize benefit for those enrolled. His precision medicine research program focuses on utilizing basic and computational biology to develop synthetic lethal drug pairs that can overcome the challenges of driver mutation targeting—and eventually offer a wider percentage of patients effective therapeutic options.

> Explore the NOB's Research Programs

Areas of Expertise

1) Neuro-oncology 2) Combination immunotherapy 3) Primary brain tumors 4) Ependymoma 5) Clinical trial optimization 6) Patient outcomes

Information for Patients

Learn about our multidisciplinary approach to patient care, our clinical trials and the highly specialized care teams who lead them.


Selected Recent Publications

Efficient ADCC-Killing of Meningioma by Avelumab and a high-affinity natural killer cell line, hank.

Giles AJ, Hao S, Padget MR, Song H, Zhang W, Lynes J, Sanchez VE, Liu Y, Jung J, Cao X, Fujii R, Jensen RL, Gillespie D, Schlom J, Gilbert MR, Nduom EK, Yang C, Lee JH, Soon Shiong P, Hodge JW, Park DM.
JCI Insight. Epub ahead of print. : 2019. [ Journal Article ]

Challenges to curing primary brain tumours.

Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland Ec, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich Jn, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ.
Nature Reviews Clinical Oncology. 16(8): 509-520, 2019. [ Journal Article ]

Opportunities and challenges of incorporating clinical outcome assessments in brain tumor clinical trials.

Molinari E, Mendoza TR, Gilbert MR.
Neuro-Oncology Practice. 6(2): 81-92, 2018. [ Journal Article ]

Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy.

Giles AJ, Hutchinson MND, Sonnemann HM, Jung J, Fecci PE, Ratnman NM, Zhang W, Song H, Bailey R, Davis D, Reid CM, Park DM, Gilbert MR.
Journal of Immunotherapy. 6(1): 51, 2018. [ Journal Article ]

Immunotherapy in CNS Cancers: The Role of Immune Cell Trafficking.

5. Ratnam NM, Gilbert MR, Giles AJ.
Neuro-Oncology. 21(1): 37-46, 2018. [ Journal Article ]

Job Vacancies

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