Brain Tumor Trials Collaborative

BTTC Annual Meeting Attendees

The mission of the Brain Tumor Trials Collaborative (BTTC) is to develop and perform state-of-the-art clinical trials in a collaborative and collegial environment—advancing treatments for patients with brain and spine tumors that merge sound scientific methods with concern for patient well-being.

The BTTC was created in 2003 as a network of professionals who investigate new treatments, allowing patients across the nation to participate in cutting-edge clinical trials that help medical professionals more rapidly determine the benefits of various therapies. The NCI Center for Cancer Research's Neuro-Oncology Branch (NOB) serves as the BTTC's lead institution and provides administrative infrastructure, clinical databases, and oversight for the collaborative.

The BTTC network also participates in clinical trials led by NCI-CONNECT (Comprehensive Oncology Network Evaluating Rare CNS Tumors), a program that advances our understanding of rare central nervous system (CNS) cancers in adults, in addition to fostering patient-advocacy-provider partnerships. By collaborating with advocacy organizations as well as BTTC doctors and institutions, NCI-CONNECT researchers hope to improve approaches to care and treatment for rare CNS tumors.

Clinical trials are medical research studies conducted to understand whether promising approaches to cancer prevention, diagnosis, and treatment are safe and effective in patients. Since its inception, the BTTC has spearheaded unparalleled advancements in the research of brain and spine tumors, and completed many clinical trials that increase survival and improve quality of life.

Completed BTTC Clinical Trials

The BTTC has launched eight clinical trials since its inception in 2003. These clinical trials, listed below, are now closed to accrual.

Open NCI-CONNECT Clinical Studies

The BTTC network is also participating in two multi-center NCI-CONNECT clinical studies that are currently enrolling.

Updated: September 1, 2022

Published Papers

BTTC Annual Meetings

  • 2019: The NCI-CONNECT and BTTC Annual Meetings were held from April 29 to 30, 2019 at the NIH. Learn more >
  • 2018: The inaugural NCI-CONNECT Meeting was held in conjunction with the BTTC Annual Meeting from June 11 to 12, 2018 at the NIH. Learn more >
  • 2017: The BTTC held its Annual Meeting on March 31, 2017 at the NIH. Learn more >

​​​​​​​Updated: September 1, 2022

Each of the participating BTTC and NCI-CONNECT institutions are committed to discovering new and effective therapies for treating brain and spine tumors, while providing compassionate care to enhance patient outcomes and well-being. Contact the NCI Center for Cancer Research's Neuro-Oncology Branch (NOB) if you have questions about BTTC or NCI-CONNECT clinical trials by emailing or calling (240) 760-6010. Learn more about participating institutions and investigators by clicking the markers on the map.