Brain Tumor Trials Collaborative

BTTC Annual Meeting Attendees

The mission of the Brain Tumor Trials Collaborative (BTTC) is to develop and perform state-of-the-art clinical trials in a collaborative and collegial environment—advancing treatments for patients with brain and spine tumors that merge sound scientific methods with concern for patient well-being.

The BTTC was created in 2003 as a network of professionals who investigate new treatments, allowing patients across the nation to participate in cutting-edge clinical trials that help health care providers more rapidly determine the benefits of various therapies. The NCI Center for Cancer Research's Neuro-Oncology Branch (NOB) serves as the BTTC's lead institution and provides administrative infrastructure, clinical databases, and oversight for the collaborative.

In 2018, the BTTC network of 33 institutions joined NCI-CONNECT (Comprehensive Oncology Network Evaluating Rare CNS Tumors), a Cancer Moonshot℠-funded program also managed at the NOB. NCI-CONNECT advances our understanding of rare central nervous system (CNS) cancers in adults by fostering patient-advocacy-provider partnerships. By collaborating with advocacy organizations and the BTTC network to perform clinical trials and care for patients, NCI-CONNECT aims to improve approaches to care and treatment for people with rare CNS tumors.

Contact our BTTC team by emailing or calling 240-760-6060.

Clinical trials are medical research studies conducted to understand whether promising approaches to cancer prevention, diagnosis, and treatment are safe and effective in patients. Since its inception, the BTTC has spearheaded unparalleled advancements in the research of brain and spine tumors, and completed many clinical trials that increase survival and improve quality of life.

Completed BTTC Clinical Trials

The BTTC has launched eight clinical trials since its inception in 2003. These clinical trials, listed below, are now closed to accrual.

Open NCI-CONNECT Clinical Studies

The BTTC/NCI-CONNECT network is also participating in two multi-center NCI-CONNECT clinical studies that are currently enrolling.

The BTTC/NCI-CONNECT network is instrumental in referring patients to NCI-CONNECT clinical studies at NIH. 

Updated: August 31, 2023

Published Papers

BTTC Annual Program and Clinical Trial Planning Meetings

  • 2021: The NCI-CONNECT and BTTC Clinical Trial Meeting was held virtually on November 18, 2021, during the Society for Neuro-Oncology Annual Meeting.
  • 2021: The NCI-CONNECT and BTTC Annual Meetings were held virtually from July 29 to 30, 2021. 
  • 2020: The NCI-CONNECT and BTTC Annual Meetings were held virtually on August 21, 2020.
  • 2019: The NCI-CONNECT and BTTC Annual Meetings were held from April 29 to 30, 2019 at NIH. Learn more >
  • 2018: The inaugural NCI-CONNECT Meeting was held in conjunction with the BTTC Annual Meeting from June 11 to 12, 2018 at NIH. Learn more >
  • 2017: The BTTC held its Annual Meeting on March 31, 2017 at NIH. Learn more >

Updated: August 31, 2023

Each of the participating BTTC and NCI-CONNECT institutions is committed to discovering new and effective therapies for treating brain and spine tumors, while providing compassionate care to enhance patient outcomes and well-being. Contact the NOB if you have questions about BTTC or NCI-CONNECT clinical trials. To refer a patient, email or call (240) 760-6010. Learn more about participating institutions by clicking the markers on the map below.