Breadcrumb

Maria R. Parkhurst, Ph.D.

Maria R. Parkhurst, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Surgery Branch

RESEARCH SUMMARY

The primary responsibilities of the Peptide Synthesis and Antigen Discovery Core are to identify populations of tumor reactive T lymphocytes and identify new tumor reactive T cell receptors for use in clinical trials of gene-engineered lymphocytes for patients with metastatic solid tumors.

Areas of Expertise

1) T cells 2) gene therapy 3) peptide synthesis

Publications

Selected Publications

A high avidity WT1 reactive T cell receptor mediates recognition of peptide and processed antigen but not naturally occurring WT1 positive tumor cells

Jaigirdar, A, Rosenberg, SA, Parkhurst, M.
J Immunother. 39(3): 105-16, 2016. [ Journal Article ]

Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System

Deniger DC, Pasetto A, Tran E, Parkhurst MR, Cohen CJ, Robbins PF, Cooper LJ, Rosenberg SA
Mol Ther.. Mar 5: epub ahead of print, 2016. [ Journal Article ]

Prospective identification of cancer mutation-specific lymphocytes in peripheral blood of melanoma patients

Gros, A, Tran, E, Parkhurst, M, Pasetto, A, Robbins, P, Ilyas, S, Prickett, T, Gartner, J, Crystal, J, Roberts, I, Trebska-McGowan, K, Wunderlich, J, Yang, J, Rosenberg SA
Nat Med.. 22(4): 433-8, 2016.

Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes

Cohen, C, Gartner, J, Horovitz-Fried, M, Shamalov, K, Trebska-McGowan, K, Bliskovsky, V, Parkhurst, M, Ankri, C, Prickett, T, Li, Y, El-Gamil, M, Crystal, J, Rosenberg, SA, Robbins, P
J Clin Invest. 125(10): 3981-91, 2015.

Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer

Tran E, Turcotte S, Gros A, Robbins PF, Lu Y, Dudley ME, Wunderlich JR, Somerville RP, Hogan K, Hinrichs CS, Parkhurst MR, Yang JC, Rosenberg SA.
Science. 344: 641-5, 2014. [ Journal Article ]

Team

Scientist (Contr.)
Alakesh Bera, Ph.D.
Postbaccalaureate Fellow
Maria Florentin
Postbaccalaureate Fellow
Robert Masi