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Lisa Boxer

Lisa D. Boxer, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Stadtman Investigator
Laboratory of Genome Integrity

RESEARCH SUMMARY

The Boxer lab studies the role of chromatin regulation in neural development and how mutations in chromatin regulators lead to neurodevelopmental disorders and cancer. Current projects in the lab focus on specific types of DNA methylation found in neurons and the proteins associated with these modifications.

Areas of Expertise

Chromatin Regulation
Transcription
DNA Methylation
MeCP2
Neural Development and Disorders

Publications

Selected Recent Publications

Activity-induced MeCP2 phosphorylation regulates retinogeniculate synapse refinement

Tzeng CP*, Whitwam T*, Boxer LD*, Li E, Silberfeld A, Trowbridge S, Mei K, Lin C, Shamah R, Griffith EC, Renthal W, Chen C, Greenberg ME. (*co-first author)
PNAS. 120(44):e2310344120: 2023. [ Journal Article ]

MeCP2 represses the rate of transcriptional initiation of highly methylated long genes

Boxer LD*, Renthal W*, Greben AW, Whitwam T, Silberfeld A, Stroud H, Li E, Yang MG, Kinde B, Griffith EC, Bonev B, Greenberg ME. (*co-first author)
Molecular Cell. 77(2): 294–309, 2020. [ Journal Article ]

Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing

Renthal W*, Boxer LD*, Hrvatin S, Li E, Silberfeld A, Nagy MA, Griffith EC, Vierbuchen T, Greenberg ME. (*co-first author)
Nature Neuroscience. 21(12): 1670–1679, 2018. [ Journal Article ]

Early-life gene expression in neurons modulates lasting epigenetic states

Stroud H, Su SC, Hrvatin S, Greben AW, Renthal W, Boxer LD, Nagy MA, Hochbaum DR, Kinde B, Gabel HW, Greenberg ME.
Cell. 171(5): 1151–1164, 2017. [ Journal Article ]

ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes

Boxer LD, Barajas B, Tao S, Zhang J, Khavari PA
Genes & Development. 28(18): 2013–2026, 2014. [ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Postdoctoral Fellow - Neuronal development and disorders, Chromatin regulation Ph.D. or equivalent Lisa Boxer lisa.boxer@nih.gov
Biologist - Neurodevelopmental disorders, cancer B.S./B.A. or equivalent Lisa Boxer lisa.boxer@nih.gov

News

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Team

Rosy Sakr
POSTDOCTORAL FELLOW (VISITING)
Rosy Sakr, Ph.D.
Tyler
Postbaccalaureate (CRTA)
Tyler Masuda, B.Sc.
Maya
Postbaccalaureate (CRTA)
Maya Larbi, B.Sc.