KyeongEun  Lee, Ph.D.

KyeongEun Lee, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. KyeongEun Lee has made a significant impact on research efforts involving HIV nuclear entry and HIV integration processes, which provide a better understanding of early stages of HIV-1 replication and further help the understanding of mechanisms of HIV pathogenesis.

Areas of Expertise

Virus-host Interactions
Animal Models For HIV Infection
HIV Pathogenesis
Molecular Virology
Viral Immunology


Selected Publications

Flexible use of nuclear import pathways by HIV-1

Lee K, Ambrose Z, Martin TD, Oztop I, Mulky A, Julias JG, Vandegraaff N, Baumann JG, Wang R, Yuen W, Takemura T, Shelton K, Taniuchi I, Li Y, Sodroski J, Littman DR, Coffin JM, Hughes SH, Unutmaz D, Engelman A, KewalRamani VN.
Cell Host Microbe. 7: 221-33, 2010. [ Journal Article ]

HIV-1 capsid-targeting domain of cleavage and polyadenylation specificity factor 6

Lee K, Mulky A, Yuen W, Martin TD, Meyerson NR, Choi L, Yu H, Sawyer SL, Kewalramani VN.
J. Virol.. 86: 3851-60, 2012. [ Journal Article ]

Human immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection.

3. Ambrose Z, Lee K, Ndjomou J, Xu H, Oztop I, Matous J, Takemura T, Unutmaz D, Engelman A, Hughes SH, KewalRamani VN.
J. Virol.. 86: 4708-14, 2012. [ Journal Article ]

CPSF6 defines a conserved capsid interface that modulates HIV-1 replication.

Price AJ, Fletcher AJ, Schaller T, Elliott T, Lee K, KewalRamani VN, Chin JW, Towers GJ, James LC.
PLoS Pathog.. 8: e1002896, 2012. [ Journal Article ]

HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency

Schaller T, Ocwieja KE, Rasaiyaah J, Price AJ, Brady TL, Roth SL, Hué S, Fletcher AJ, Lee K, KewalRamani VN, Noursadeghi M, Jenner RG, James LC, Bushman FD, Towers GJ.
PLoS Pathog.. 7: e1002439, 2011. [ Journal Article ]