Kenneth H. Kraemer, M.D.

Kenneth H. Kraemer, M.D.

  • Center for Cancer Research
  • National Cancer Institute


We investigated the role of DNA repair in prevention of cancer and in human development. We performed clinical, molecular, and translational investigations of two rare genetic disorders with defective DNA repair:  xeroderma pigmentosum (XP) with clinical and cellular hypersensitivity to ultraviolet radiation and a 10,000-fold increased risk of skin cancer and trichothiodystrophy, a disorder with developmental abnormalities and defects in some of the same genes as XP without increased cancer risk. We found that the molecular changes in skin melanomas from the XP patients were closely related to sun exposure and different from the general population.

Areas of Expertise

Rare Tumors
Molecular Mechanisms Of Cancer
Melanoma/Skin Cancer
DNA Repair
UV Damage
Xeroderma Pigmentosum


Selected Recent Publications

Xeroderma Pigmentosum: A Model for Human Premature Aging

Elizabeth R H Rizza, John J DiGiovanna, Sikandar G Khan, Deborah Tamura, Jack D Jeskey, Kenneth H Kraemer
Journal of Investigative Dermatology. 141/4: 976-984, 2021. [ Journal Article ]

Reproductive Health in Xeroderma Pigmentosum: Features of Premature Aging

Melissa Merideth, Deborah Tamura, Divya Angra, Sikandar G Khan, Joyln Ferrell, Alisa M Goldstein, John J DiGiovanna, Kenneth H Kraemer
Obstetrics and Gynecology. 134 (4): 814-819, 2019. [ Journal Article ]

Four-dimensional, dynamic mosaicism is a hallmark of normal human skin that permits mapping of the organization and patterning of human epidermis during terminal differentiation

Yun Wang, Taro Masaki, Sikandar G Khan, Deborah Tamura, Christiane Kuschal, Megan Rogers, John J DiGiovanna, Kenneth H Kraemer
Public Library of Science. June: 2018. [ Journal Article ]

Use of Big Data to Estimate Prevalence of Defective DNA Repair Variants in the US Population

Pugh J, Khan SG, Tamura D, Goldstein AM, Landi MT, DiGiovanna JJ, Kraemer KH.
JAMA Dermatol. 155(1): 72-78, 2019. [ Journal Article ]

Shining a light on xeroderma pigmentosum

John J DiGiovanna, Kenneth H Kraemer
Journal of Investigative Dermatology. 132/3: 785-796, 2012. [ Journal Article ]