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Kenneth H. Kraemer, M.D.

Kenneth H. Kraemer, M.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

We are investigating the role of DNA repair in prevention of cancer and in human development. We perform clinical, molecular, and translational investigations of two rare genetic disorders with defective DNA repair: xeroderma pigmentosum (XP) with clinical and cellular hypersensitivity to ultraviolet radiation and a 10,000-fold increased risk of skin cancer and trichothiodystrophy, a disorder with developmental abnormalities and defects in some of the same genes as XP without increased cancer risk. We recently found that the molecular changes in skin melanomas from the XP patients were closely related to sun exposure and different from the general population.

Areas of Expertise

1) DNA repair 2) UV damage 3) skin cancer 4) primary melanoma 5) xeroderma pigmentosum 6) trichothiodystrophy

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them. 

Publications

Selected Recent Publications

Xeroderma Pigmentosum: A Model for Human Premature Aging

Elizabeth R H Rizza, John J DiGiovanna, Sikandar G Khan, Deborah Tamura, Jack D Jeskey, Kenneth H Kraemer
Journal of Investigative Dermatology. 141/4: 976-984, 2021. [ Journal Article ]

Reproductive Health in Xeroderma Pigmentosum: Features of Premature Aging

Melissa Merideth, Deborah Tamura, Divya Angra, Sikandar G Khan, Joyln Ferrell, Alisa M Goldstein, John J DiGiovanna, Kenneth H Kraemer
Obstetrics and Gynecology. 134 (4): 814-819, 2019. [ Journal Article ]

Four-dimensional, dynamic mosaicism is a hallmark of normal human skin that permits mapping of the organization and patterning of human epidermis during terminal differentiation

Yun Wang, Taro Masaki, Sikandar G Khan, Deborah Tamura, Christiane Kuschal, Megan Rogers, John J DiGiovanna, Kenneth H Kraemer
Public Library of Science. June: 2018. [ Journal Article ]

Use of Big Data to Estimate Prevalence of Defective DNA Repair Variants in the US Population

Pugh J, Khan SG, Tamura D, Goldstein AM, Landi MT, DiGiovanna JJ, Kraemer KH.
JAMA Dermatol. 155(1): 72-78, 2019. [ Journal Article ]

Shining a light on xeroderma pigmentosum

John J DiGiovanna, Kenneth H Kraemer
Journal of Investigative Dermatology. 132/3: 785-796, 2012. [ Journal Article ]

Job Vacancies

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Team

Senior Clinical Research Nurse
Deborah E. Tamura, R.N., M.S.
Biologist
Xiaoling (Charlene) Zhou, Ph.D.
Postbaccalaureate Fellow (CRTA)
Elvelyn Fernandez , B.S.
Special Volunteer
Sandra Folarin
Special Volunteer
Elizabeth Heller Rizza , M.D.
Special Volunteer
Jack Jeskey , B.S.