Kenneth Aldape, M.D.

Kenneth Aldape, M.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Aldape is a molecular neuropathologist with a focus on the molecular basis and classification of brain tumors.  From a broader perspective, he is interested in the use of new technologies (genomic, computational) that contribute to precision diagnostics of cancer, and ultimately improved patient outcomes.

Areas of Expertise

Molecular Genomics of Brain Tumors
Diagnostic Neuropathology
Precision Diagnostics


Selected Key Publications

cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas.

Brat DJ, Aldape K, Colman H, Figrarella-Branger D, Fuller GN, Giannini C, Holland EC, Jenkins RB, Kleinschmidt-DeMasters B, Komori T, Kros JM, Louis DN, McLean C, Perry A, Reifenberger G, Sarkar C, Stupp R, van den Bent MJ, von Deimling A, Weller M.
Acta Neuropathol.. 139(3): 603-8, 2020. [ Journal Article ]

Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and WNT.

El-Sehemy A, Selvadurai HJ, Ortin-Martinez A, Pokrajac NT, Mamatjan Y, Tachibana N, Rowland KJ, Lee L, Park NI, Aldape KD, Dirks P, Wallace VA.
J Clin Invest.. In press: 2020. [ Journal Article ]

Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma

Bhat KPL, Balasubramaniyan V, Vaillant B, Ezhilarasan R, Hummelink K, Hollingsworth F, Wani K, Heathcock L, James JD, Goodman LD, Conroy S, Long L, Lelic N, Wang S, Gumin J, Raj D, Kodama Y, Raghunathan A, Olar A, Joshi K, Pelloski CE, Heimberger A, Kim SH, Cahill DP, Rao G, Den Dunnen WFA, Boddeke HW, Phillips HS, Nakano I, Lang FF, Colman H, Sulman EP, Aldape K.
Cancer Cell. 24(3): 331-46, 2013. [ Journal Article ]

Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas

Agnihotri S, Suppiah S, Tonge PD, Jalali S, Danesh A, Bruce JP, Mamatjan Y, Klironomos G, Gonen L, Au K, Mansouri S, Karimi S, Sahm F, von Deimling A, Taylor MD, Laperriere NJ, Pugh TJ, Aldape KD*, Zadeh G*. *co-corresponding author
Nature Communications. 8(1): 186, 2017. [ Journal Article ]

The genomic landscape of schwannoma

Agnihotri S, Jalali S, Wilson MR, Danesh A, Li M, Klironomos G, Krieger JR, Mansouri A, Khan O, Mamatjan Y, Landon-Brace N, Tung T, Dowar M, Li T, Bruce JP, Burrell KE, Tonge PD, Alamsahebpour A, Krischek B, Agarwalla PK, Bi WL, Dunn IF, Beroukhim R, Fehlings MG, Bril V, Pagnotta SM, Iavarone A, Pugh TJ, Aldape KD*, Zadeh G*. *co-corresponding author
Nature Genetics. 48(11): 1339-1348, 2016. [ Journal Article ]

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Scientist (Contr.)
Hye-Jung Chung, Ph.D.
Biological Scientist
Karen Dazelle
Project Manager (Contr.)
Yu Jin Lee
Research Fellow (VP)
Di Wu
Postdoctoral Fellow (Visiting)
Bharati Mehani, Ph.D.
Visiting Fellow
Saleembhasha Asanigari
Postdoctoral Fellow (CRTA)
Zhichao Wu, Ph.D.