Breadcrumb

Kenneth Aldape, M.D.

Kenneth Aldape, M.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Aldape is a molecular neuropathologist with a focus on the molecular basis and classification of brain tumors.  From a broader perspective, he is interested in the use of new technologies (genomic, computational) that contribute to precision diagnostics of cancer, and ultimately improved patient outcomes.

Areas of Expertise

1) molecular genomics of brain tumors 2) diagnostic neuropathology 3) precision diagnostics 4) epigenomic signatures of cancer

Publications

Selected Key Publications

cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas.

Brat DJ, Aldape K, Colman H, Figrarella-Branger D, Fuller GN, Giannini C, Holland EC, Jenkins RB, Kleinschmidt-DeMasters B, Komori T, Kros JM, Louis DN, McLean C, Perry A, Reifenberger G, Sarkar C, Stupp R, van den Bent MJ, von Deimling A, Weller M.
Acta Neuropathol.. 139(3): 603-8, 2020. [ Journal Article ]

Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and WNT.

El-Sehemy A, Selvadurai HJ, Ortin-Martinez A, Pokrajac NT, Mamatjan Y, Tachibana N, Rowland KJ, Lee L, Park NI, Aldape KD, Dirks P, Wallace VA.
J Clin Invest.. In press: 2020. [ Journal Article ]

Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma

Bhat KPL, Balasubramaniyan V, Vaillant B, Ezhilarasan R, Hummelink K, Hollingsworth F, Wani K, Heathcock L, James JD, Goodman LD, Conroy S, Long L, Lelic N, Wang S, Gumin J, Raj D, Kodama Y, Raghunathan A, Olar A, Joshi K, Pelloski CE, Heimberger A, Kim SH, Cahill DP, Rao G, Den Dunnen WFA, Boddeke HW, Phillips HS, Nakano I, Lang FF, Colman H, Sulman EP, Aldape K.
Cancer Cell. 24(3): 331-46, 2013. [ Journal Article ]

Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas

Agnihotri S, Suppiah S, Tonge PD, Jalali S, Danesh A, Bruce JP, Mamatjan Y, Klironomos G, Gonen L, Au K, Mansouri S, Karimi S, Sahm F, von Deimling A, Taylor MD, Laperriere NJ, Pugh TJ, Aldape KD*, Zadeh G*. *co-corresponding author
Nature Communications. 8(1): 186, 2017. [ Journal Article ]

The genomic landscape of schwannoma

Agnihotri S, Jalali S, Wilson MR, Danesh A, Li M, Klironomos G, Krieger JR, Mansouri A, Khan O, Mamatjan Y, Landon-Brace N, Tung T, Dowar M, Li T, Bruce JP, Burrell KE, Tonge PD, Alamsahebpour A, Krischek B, Agarwalla PK, Bi WL, Dunn IF, Beroukhim R, Fehlings MG, Bril V, Pagnotta SM, Iavarone A, Pugh TJ, Aldape KD*, Zadeh G*. *co-corresponding author
Nature Genetics. 48(11): 1339-1348, 2016. [ Journal Article ]

Job Vacancies

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Team

Biologist
Russell Bandle
Scientist (Contr.)
Hye-Jung Chung, Ph.D.
Project Manager (Contr.)
Yu Jin Lee
Postdoctoral Fellow (Visiting)
Bharati Mehani, Ph.D.
Postdoctoral Fellow (CRTA)
Zhichao Wu, Ph.D.