Photo of Zied Abdullaev, Ph.D.

Zied Abdullaev, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Pathology


Decoding the Complexity of Human Diseases: A Multiomics Approach

As a dedicated researcher, my focus lies in unraveling the intricate complexities inherent in human diseases, with a particular emphasis on cancer. While genetic mutations undoubtedly provide valuable insights into complex diseases, my methodology transcends conventional genetic analyses. I am focused on a comprehensive exploration of the epigenetic modifications, genomic alterations, and transcriptome, collectively referred to as multiomics. This sophisticated approach not only facilitates a nuanced understanding of disease origins but also contributes to the development of advanced diagnostic and treatment strategies.

Genomic Signatures for Personalized Therapeutic Interventions

A significant aspect of my work involves characterizing the biology of specific genomic and epigenomic alterations in Central Nervous System tumors. These alterations play a crucial role in the molecular pathogenesis and treatment resistance exhibited by aggressive brain tumors. By unraveling the intricacies of such alterations, we gain insights that inform clinical decision-making. Employing genomic signatures, my overarching goal is to discern clinically relevant subclasses. These subclasses guide bespoke therapeutic interventions, ultimately improving patient outcomes.

Embracing Computational Tools and AI

I am excited about the integration of new computational and machine learning tools in the analysis of multiomics and clinical data. Leveraging these tools, in conjunction with AI, shows promise in enhancing the precision and accuracy of cancer diagnostics. Our collective efforts pave the way for targeted therapeutic interventions that can transform patient care.