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Jagan R. Muppidi, M.D., Ph.D.

Jagan R. Muppidi, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Lymphoid Malignancies Branch

RESEARCH SUMMARY

Dr. Muppidi is an Earl Stadtman Investigator in the Lymphoid Malignancies Branch, NCI. He is interested in understanding the intersection of the immune response and generation of malignancies derived from B cells. The goal of his research is to define how genetic changes found in B cell lymphomas contribute to altered B cell behavior within the microenvironment and the subsequent development of malignancy.

Areas of Expertise

1) germinal center B cells 2) lymphoma pathogenesis

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Publications

Selected Key Publications

Aberrant expansion of spontaneous splenic germinal centers induced by hallmark genetic lesions of aggressive lymphoma

Pindzola GM, Razzaghi R, Tavory RN, Nguyen HT, Morris VM, Li M, Agarwal S, Huang B, Okada T, Reinhardt HC, Knittel G, Kashkar H, Young RM, Pittaluga S & Muppidi, JR
Blood. 2022.
Full-Text Article
[ Journal Article ]

Compromised counterselection by FAS creates an aggressive subtype of germinal center lymphoma.

Razzaghi R, Agarwal S, Kotlov N, Plotnikova O, Nomie K, Huang DW, Wright GW, Smith GA, Li M, Takata K, Yamadi M, Yao C, O’Shea JJ, Phelan JD, Pittaluga S, Scott DW & Muppidi JR
J Exp Med. 218 (3): e20201173, 2021.
Full-Text Article
[ Journal Article ]

TGFβ signaling in germinal center B cells promotes the transition from light zone to dark zone

Albright AR, Kabat J, Li M, Raso F, Reboldi A and Muppidi JR
J Exp Med. 216 (11): 2531–2545, 2019.
Full-Text Article
[ Journal Article ]

S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8.

Lu E, Wolfreys FD, Muppidi JR, Xu Y and Cyster JG.
Nature. 567(7747): 244-248, 2019. [ Journal Article ]

Loss of signaling via Gα13 in germinal centre B-cell-derived lymphoma

Muppidi JR, Schmitz R, Green JA, Xiao W, Larsen AB, Braun SE, An J, Xu Y, Rosenwald A, Ott G, Gascoyne RD, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Vaidehi N, Staudt LM, and Cyster JG.
Nature. 516(7530): 254-8, 2014. [ Journal Article ]

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Team

Postdoctoral Fellow (Visiting)
Hang Nguyen, Ph.D.
Scientist (Contr.)
Moyi Li
Postbaccalaureate Fellow (CRTA)
Enoc Granados Centeno
Postbaccalaureate Fellow (CRTA)
Sriranjani Darbha

Covers

TGFβ signaling in the germinal center

TGFβ signaling in germinal center B cells promotes the transition from light zone to dark zone

Published Date

Albright et al. describe the previously unknown function of TGFβ in promoting the transition of GCB cells from LZ to DZ. The cover shows staining for phosphorylated Smad2 (red) in a Peyer’s patch from a wild-type mouse.

Citation
TGFβ signaling in germinal center B cells promotes the transition from light zone to dark zone. 
Albright AR, Kabat J, Li M, Raso F, Reboldi A and Muppidi JR. J Exp Med. 216(11):2531-2545, 2019. 
The origin of MCD-DLBCL

MCD-DLBCL arises from spontaneous splenic germinal centers

Spleen cryosection of a mouse model of MCD (mutant MYD88/CD79B) lymphoma stained for IgD (brown) and CD4 (blue). MCD lymphoma precursor cells can infiltrate the spleen where they can develop into lymphoma.

Citation

Aberrant expansion of spontaneous splenic germinal centers induced by hallmark genetic lesions of aggressive lymphoma. Pindzola GM, Razzaghi R, Tavory RN, Nguyen HT, Morris VM, Li M, Agarwal S, Huang B, Okada T, Reinhardt HC, Knittel G, Kashkar H, Young RM, Pittaluga S & Muppidi, JR. Blood. 2022.