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Hisataka  Kobayashi, M.D., Ph.D.

Hisataka Kobayashi, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Molecular Imaging Branch

RESEARCH SUMMARY

Dr. Hisataka Kobayashi is a Senior Investigator in the Molecular Imaging Branch at the National Cancer Institute/ NIH in Bethesda, MD. Dr. Kobayashi was awarded an M.D. and Ph.D. (Immunology/Medicine) from the Kyoto University, Kyoto, Japan. His interest is in developing the novel molecular imaging and therapeutic agents or technologies especially for targeting cancers. He has published over 250 scientific articles in clinical and preclinical bio-medical imaging over the last 20 years.

Areas of Expertise

1) molecular imaging, 2) photo-immunotherapy, 3) molecular probe chemistry

Publications

Selected Publications

Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine

Liu XF, Wei J, Zhou Q, Molitoris BA, Sandoval R, Kobayashi H, Okada R, Nagaya T, Karim B, Butcher D, Pastan I.
Proc Natl Acad Sci U S A. 117(11): 6086-91, 2020. [ Journal Article ]

Combined CD44- and CD25-Targeted Near-Infrared Photoimmunotherapy Selectively Kills Cancer and Regulatory T Cells in Syngeneic Mouse Cancer Models

Maruoka Y, Furusawa A, Okada R, Inagaki F, Fujimura D, Wakiyama H, Kato T, Nagaya T, Choyke PL, Kobayashi H.
Cancer Immunol Res. 8(3): 345-55, 2020. [ Journal Article ]

Near-Infrared Photoimmunotherapy of Cancer

Kobayashi H, Choyke PL.
Acc Chem Res. 52(8): 2332-39, 2019. [ Journal Article ]

Host Immunity Following Near-Infrared Photoimmunotherapy Is Enhanced with PD-1 Checkpoint Blockade to Eradicate Established Antigenic Tumors

Nagaya T, Friedman J, Maruoka Y, Ogata F, Okuyama S, Clavijo PE, Choyke PL, Allen C, Kobayashi H.
Cancer Immunol Res. 7(3): 401-13, 2019. [ Journal Article ]

Photoinduced Ligand Release from a Silicon Phthalocyanine Dye Conjugated with Monoclonal Antibodies: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy

Sato K, Ando K, Okuyama S, Moriguchi S, Ogura T, Totoki S, Hanaoka H, Nagaya T, Kokawa R, Takakura H, Nishimura M, Hasegawa Y, Choyke PL, Ogawa M, Kobayashi H.
ACS Cent Sci. 4(11): 1559-69, 2018. [ Journal Article ]

Job Vacancies

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Team

Staff Scientist
Aki Furusawa , Ph.D.
Special Volunteer
Fuyuki Inagaki, M.D., Ph.D.
Special Volunteer
Shuhei Okuyama, MEng
Special Volunteer
Hideyuki Furumoto, M.D., Ph.D.
Postdoctoral Fellow (Visiting)
Hiroshi Fukushima, M.D., Ph.D.
Postdoctoral Fellow (Visiting)
Seiichiro Takao, M.D., Ph.D.

Alumni

Andrew J. Gunn
Andrew J. Gunn
2006-2007
HHMI student
Yoshinori Koyama, M.D.
Yoshinori Koyama, M.D.
2005-2007
Post-doctoral Fellow
Michelle Longmire
Michelle Longmire
2007-2008, 2009-2010
HHMI student
Nobuyuki Kosaka, M.D., Ph.D.
Nobuyuki Kosaka, M.D., Ph.D.
2007-2010
Post-doctoral Fellow
Mikako Ogawa, Ph.D.
Mikako Ogawa, Ph.D.
2007-2009
Post-doctoral Fellow
Raphael Alford
Raphael Alford
2008-2009
CRTP student
Thomas McCann
Thomas McCann
2009-2010
CRTP student
Lauren Rosenblum
Lauren Rosenblum
2009-2010
Post-Baccalaureate Student
Makoto Mitsunaga, M.D., Ph.D.
Makoto Mitsunaga, M.D., Ph.D.
2009-2011
Post-doctoral Fellow
Takahito Nakajima
Takahito Nakajima
2010-2013
Post-doctoral Fellow
Kohei Sano, Ph.D.
Kohei Sano, Ph.D.
2011-2013
Post-doctoral Fellow
Vinita Alexander
Vinita Alexander
2011-2012
HHMI student
Towhid Ali
Towhid Ali
2012-2013
CRTP student
Toshiko Harada, M.D.
Toshiko Harada, M.D.
2013-2015
Special Volunteer
Yukihiro Hama, M.D., Ph.D.
Yukihiro Hama, M.D., Ph.D.
2005-2006
Post-doctoral Fellow
Rira Watanabe, Ph.D.
Rira Watanabe, Ph.D.
2013-2014
Special Volunteer
Tristan Barrett
Tristan Barrett
2005-2007
Post-doctoral Fellow
Hirofumi Hanaoka, Ph.D.
Hirofumi Hanaoka, Ph.D.
2013-2014
Post-doctoral Fellow
Daiki Fujimura, MEng
Daiki Fujimura, MEng
2018-2020
Special Volunteer
Yasuhiro Maruoka, M.D., Ph.D.
Yasuhiro Maruoka, M.D., Ph.D.
2017-2019; 2019-2020
Post-doctoral Fellow; Special Volunteer
Ryuhei Okada, M.D., Ph.D.
Ryuhei Okada, M.D., Ph.D.
2018-2021
Post-doctoral Fellow
Hiroaki Wakiyama
Hiroaki Wakiyama
2019-2022
Postdoctoral Fellow (Visiting)
Takuya Kato, M.D., Ph.D.
Takuya Kato, M.D., Ph.D.
2019-2022
Post-doctoral Fellow (Visiting)