Giovanna Tosato, M.D.

Giovanna Tosato, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Cellular Oncology


Dr. Tosato is a physician/scientist who has played an important role in dissecting the pathogenesis of Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) infection, immortalization, and tumorigenesis. Endothelial cells are critical targets of KSHV infection. Her research is now broadly focused on endothelial cells, their functions and regulation through genetic, epigenetic, and biochemical mechanisms, particularly on the role of endothelial cells as components of the tumor microenvironment and development of novel therapies for targeting the tumor vasculature.

Areas of Expertise

Endothelial Cell Functions and Molecular Mechanisms
Ephrin Ligands and Eph Receptors
Endothelial Cells and Hematopoiesis


Selected Key Publications

Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth

Wang Y, Salvucci O, Ohnuki H, Tran AD, Ha T, Feng JX, DiPrima M, Kwak H, Wang D, Yu Y, Kruhlak M, Tosato G.
EMBO Molecular Medicine. Vol. 13 Issue 7: 2021.
Full-Text Article

Iterative epigenomic analyses in the same single cell

Ohnuki H, Venzon DJ, Lobanov A, Tosato G.
Genome Research. December: 2021.
Full-Text Article
[ Journal Article ]

DLC1 deficiency and YAP signaling drive endothelial cell contact inhibition of growth and tumorigenesis

Ritchey L, Ha T, Otsuka A, Kabashima K, Wang D, Wang Y, Lowy DR, and Tosato G.
Oncogene. 38: 7046-7059, 2019. [ Journal Article ]

Antisense transcription from lentiviral gene targeting linked to an integrated stress response in colorectal cancer cells.

Ha T, DiPrima M, Koparde V, Jailwala P, Ohnuki H, Feng JX, Palangat M, Larson D, Tosato G.
Mol Ther Nucleic Acids. . 2022 May 18;28: 877-891, 2022.
Full-Text Article

Optimization of the Lead Compound NVP-BHG712 as a Colorectal Cancer Inhibitor.

Tröster A, DiPrima M, Jores N, Kudlinzki D, Sreeramulu S, Gande SL, Linhard V, Ludig D, Schug A, Saxena K, Reinecke M, Heinzlmeir S, Leisegang MS, Wollenhaupt J, Lennartz F, Weiss MS, Kuster B, Tosato G, Schwalbe H
Chemistry. Apr 21;29(23): e202203967, 2023.
Full-Text Article
[ Journal Article ]

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