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Giovanna Tosato, M.D.

Giovanna Tosato, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Cellular Oncology

RESEARCH SUMMARY

Dr. Tosato is a physician/scientist who has played an important role in dissecting the pathogenesis of Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) infection, immortalization, and tumorigenesis. Endothelial cells are critical targets of KSHV infection. Her research is now broadly focused on endothelial cells, their functions and regulation through genetic, epigenetic, and biochemical mechanisms, particularly on the role of endothelial cells as components of the tumor microenvironment and development of novel therapies for targeting the tumor vasculature.

Areas of Expertise

1) endothelial cell functions and molecular mechanisms 2) ephrin ligands and Eph receptors 3) endothelial cells and hematopoiesis 4) tumor endothelium and the tumor microenvironment 5) EBV- and KSHV-associated malignancies 6) endothelial cell tumorigenesis and angiosarcoma

Publications

Selected Key Publications

Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth

Wang Y, Salvucci O, Ohnuki H, Tran AD, Ha T, Feng JX, DiPrima M, Kwak H, Wang D, Yu Y, Kruhlak M, Tosato G.
EMBO Molecular Medicine. Vol. 13 Issue 7: 2021.
Full-Text Article

Iterative epigenomic analyses in the same single cell

Ohnuki H, Venzon DJ, Lobanov A, Tosato G.
Genome Research. December: 2021.
Full-Text Article
[ Journal Article ]

DLC1 deficiency and YAP signaling drive endothelial cell contact inhibition of growth and tumorigenesis

Ritchey L, Ha T, Otsuka A, Kabashima K, Wang D, Wang Y, Lowy DR, and Tosato G.
Oncogene. 38: 7046-7059, 2019. [ Journal Article ]

Identification of Eph receptor signaling as a regulator of autophagy and a therapeutic target in colorectal carcinoma

DiPrima M, Wang D, Troster A, Maric D, Terrades-Garcia N, Ha T, Kwak H, Sanchez-Martin D, Kudlinzki D, Schwalbe H and Tosato G.
Molecular Oncology. 13/11: Pages 2441-2459, 2019.
Full-Text Article
[ Journal Article ]

Effects of DLC1 Deficiency on Endothelial Cell Contact Growth Inhibition and Angiosarcoma Progression

Sánchez-Martín D, Otsuka A, Kabashima K, Ha T, Wang D, Qian X, Lowy DR, Tosato G
J Natl Cancer Inst.. 2018 Apr 1: 110(4):390-399. doi: 10.1093/jnci/djx219, 2018. [ Journal Article ]

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